Nitric oxide–releasing aspirin and indomethacin are potent inhibitors against colon cancer in azoxymethane-treated rats: effects on molecular targets
CV Rao, BS Reddy, VE Steele, CX Wang, X Liu… - Molecular cancer …, 2006 - AACR
Nitric oxide–releasing nonsteroidal anti-inflammatory drugs (NO-NSAID) are promising
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …
chemoprevention agents; unlike conventional NSAIDs, they seem free of appreciable …
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs …
JL Williams, S Borgo, I Hasan, E Castillo, F Traganos… - Cancer Research, 2001 - AACR
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NO-NSAIDs), consisting of a
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …
known nonsteroidal anti-inflammatory drug (NSAID) and a nitric oxide (NO)-releasing group …
NO-donating nonsteroidal antiinflammatory drugs (NSAIDs) inhibit colon cancer cell growth more potently than traditional NSAIDs: a general pharmacological property …
RK Yeh, J Chen, JL Williams, M Baluch… - Biochemical …, 2004 - Elsevier
The novel nitric oxide-donating nonsteroidal antiinflammatory drugs (NO-NSAIDs),
consisting of a traditional NSAID to which a NO releasing moiety is covalently attached, may …
consisting of a traditional NSAID to which a NO releasing moiety is covalently attached, may …
Colon cancer prevention with NO-releasing NSAIDs
CS Kaza, K Kashfi, B Rigas - Prostaglandins & other lipid mediators, 2002 - Elsevier
A seminal advance in the prevention of colon cancer has been the observation that
nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of and mortality from …
nonsteroidal antiinflammatory drugs (NSAIDs) reduce the incidence of and mortality from …
Growth inhibition of human colon cancer cells by nitric oxide (NO)-donating aspirin is associated with cyclooxygenase-2 induction and β-catenin/T-cell factor signaling …
JL Williams, N Nath, J Chen, TR Hundley, J Gao… - Cancer research, 2003 - AACR
Nitric oxide (NO)-releasing aspirin (ASA), consisting of a traditional ASA molecule to which a
NO-donating moiety is covalently bound, is a promising colon cancer chemopreventive …
NO-donating moiety is covalently bound, is a promising colon cancer chemopreventive …
Chemopreventive efficacy of naproxen and nitric oxide–naproxen in rodent models of colon, urinary bladder, and mammary cancers
VE Steele, CV Rao, Y Zhang, J Patlolla, D Boring… - Cancer Prevention …, 2009 - AACR
Nonsteroidal anti-inflammatory drugs (NSAID) have been highly effective in preventing
colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon …
colon, urinary bladder, and skin cancer preclinically, and also in clinical trials of colon …
Nitric-oxide-donating NSAIDs as agents for cancer prevention
B Rigas, K Kashfi - Trends in Molecular Medicine, 2004 - cell.com
Nitric-oxide-donating nonsteroidal anti-inflammatory drugs (NO–NSAIDs), which consist of
an NSAID with an NO-donating moiety covalently attached to it, promise to contribute …
an NSAID with an NO-donating moiety covalently attached to it, promise to contribute …
Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: evidence of a tissue type-independent effect
The novel nitric oxide (NO)-donating nonsteroidal anti-inflammatory drugs (NO-NSAIDs),
which are safer than their NSAID counterparts, inhibit the growth of colon cancer cells with …
which are safer than their NSAID counterparts, inhibit the growth of colon cancer cells with …
Effects of cyclooxygenase-2 inhibitor NS-398 on APC and c-myc expression in rat colon carcinogenesis induced by azoxymethane
Y Kishimoto, K Yashima, T Morisawa, G Shiota… - Journal of …, 2002 - Springer
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been reported to protect
against the development of colon cancer; however, the mechanism (s) by which NSAIDs …
against the development of colon cancer; however, the mechanism (s) by which NSAIDs …
In vitro and in vivo evaluation of NCX 4040 cytotoxic activity in human colon cancer cell lines
Background Nitric oxide-releasing nonsteroidal antiinflammatory drugs (NO-NSAIDs) are
reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the …
reported to be safer than NSAIDs because of their lower gastric toxicity. We compared the …