We investigated the homogeneous nucleation and subsequent evolution of polymers of
sickle cell hemoglobin (HbS) using differential interference contrast (DIC) microscopy. The …

The primary pathogenic event of sickle cell anemia is the polymerization of the mutant
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …

The kinetics of the assembly of structurally distinct, polymeric aggregates constituting the
fiber-to-crystal transition of sickle cell hemoglobin in slowly stirred, deoxvgenated solutions …

Using experimentally observed processes of linear growth, heterogeneous nucleation, and
polymer bending, with no additional assumptions, we have been able to model the two …

We have used differential polarization imaging microscopy to measure the amount and
orientation of aligned sickle hemoglobin polymer in quickly deoxygenated sickle red blood …

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of
babies born each year worldwide. Its primary pathogenic event is the polymerization of a …

The polymerization of sickle hemoglobin involves the assembly of 14 stranded fibers, which
are found in dense multibranched arrays (Briehl, 1995; White & Heagan, 1970) called …

In search of novel control parameters for the polymerization of sickle cell hemoglobin (HbS),
the primary pathogenic event of sickle cell anemia, we explore the role of free heme, which …

Sickle hemoglobin (HbS) polymerization occurs when the concentration of deoxyHbS
exceeds a well-defined solubility. In experiments using sickle hemoglobin droplets …

Sickle hemoglobin polymerizes by two types of nucleation: homogeneous nucleation of
aggregates in solution, and heterogeneous nucleation on preexisting polymers. It has been …