Abstract Lately, IL-17-secreting Th cells have received an overwhelming amount of attention
and are now widely held to be the major pathogenic population in autoimmune diseases. In …

Recent studies have suggested that IL-21 is a key factor in the development of IL-17-
producing CD4 T cells (Th17) and that the induction of experimental autoimmune …

Interleukin (IL)-25 is a member of the IL-17 family of cytokines. However, unlike the other
members of this family, IL-25 promotes T helper (Th) 2 responses. We now show that IL-25 …

Until recently, autoimmune diseases had been categorized as either Th1-or Th2-mediated
diseases. However, the discovery of a novel subset of helper T cells producing interleukin …

Abstract IL-23, an IL-12 family member, has been implicated in the development of Th17
cells and the progression of autoimmune diseases. However, due to the lack of availability of …

IL-27 counters the effect of TGF-β+ IL-6 on naive CD4+ T cells, resulting in near complete
inhibition of de novo Th17 development. In contrast, little is known about the effect of IL-27 …

IL-15 is an important IL-2–related cytokine whose role in Th17 cell biology has not been fully
elucidated. In this study, we show that exogenous IL-15 decreased IL-17A production in …

Abstract Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-
23 to become encephalitogenic, but the mechanism by which IL-23 promotes their …

Summary Th17 cells, CD4+ T cells that secrete interleukin-17 (IL-17), are pathogenic in
autoimmune diseases and their development and expansion is driven by the cytokines IL-6 …

IL-23–produced by dendritic cells–and Th17 cells have both been identified as major factors
involved in autoimmune inflammation, yet their relationship with each other remains …