SUN-261 Deletion of Hepatic Kisspeptin Results in Abnormal Glucose Metabolism in Female Mice

B Aloqaily, H Kwon, AL Negron… - Journal of the …, 2020 - academic.oup.com
Kisspeptin is a hypothalamic protein critical for neuroendocrine control of pubertal
development and fertility and is modulated by nutritional signals. Kisspeptin has been …

Liver-Specific Kisspeptin Deletion Impairs Energy Metabolism in Mice

B Aloqaily, H Kwon, S Al-Samerria… - Journal of the …, 2021 - ncbi.nlm.nih.gov
Kisspeptin, a neuroendocrine protein critical for the control of pubertal development and
fertility has been shown to be modulated by nutritional signals. While the secretion of …

Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure

JAP De Bond, KP Tolson, C Nasamran… - Journal of …, 2016 - Wiley Online Library
Kisspeptin controls reproduction by stimulating gonadotrophin‐releasing hormone neurones
via its receptor Kiss1r. Kiss1r is also expressed other brain areas and in peripheral tissues …

Novel actions of kisspeptin signaling outside of GnRH-mediated fertility: a potential role in energy balance

R Patel, JT Smith - Domestic Animal Endocrinology, 2020 - Elsevier
Kisspeptin, encoded by Kiss1 gene expressing neurons in the hypothalamus, is a requisite
for fertility and now appears critical in the regulation of energy balance. Kisspeptin neurons …

Emerging roles for kisspeptin in metabolism

C Izzi‐Engbeaya, WS Dhillo - The Journal of Physiology, 2022 - Wiley Online Library
Kisspeptin, a neuropeptide hormone, has been firmly established as a key regulator of the
hypothalamic–pituitary–gonadal axis and mammalian reproductive behaviour. In recent …

Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice

NP Di Giorgio, M Bizzozzero-Hiriart… - American Journal …, 2023 - journals.physiology.org
Kisspeptin and γ-amino butyric acid (GABA), synthesized in the central nervous system, are
critical for reproduction. Both are also expressed in peripheral organs/tissues critical to …

Metabolic actions of kisspeptin signaling: Effects on body weight, energy expenditure, and feeding

AD Hudson, AS Kauffman - Pharmacology & therapeutics, 2022 - Elsevier
Kisspeptin (encoded by the Kiss1 gene) and its receptor, KISS1R (encoded by the Kiss1r
gene), have well-established roles in stimulating reproduction via central actions on …

Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity

KP Tolson, C Garcia, S Yen, S Simonds… - The Journal of …, 2014 - Am Soc Clin Investig
The neuropeptide kisspeptin regulates reproduction by stimulating gonadotropin-releasing
hormone (GnRH) neurons via the kisspeptin receptor KISS1R. In addition to GnRH neurons …

Effects of high-fat diet-induced obesity and diabetes on Kiss1 and GPR54 expression in the hypothalamic–pituitary–gonadal (HPG) axis and peripheral organs (fat …

M Dudek, PA Kołodziejski, E Pruszyńska-Oszmałek… - Neuropeptides, 2016 - Elsevier
Recent data indicates that kisspeptin, encoded by the KISS1 gene, could play a role in
transducing metabolic information into the hypothalamic–pituitary–gonadal (HPG) axis, the …

Lower FSH with normal fertility in Male mice lacking gonadotroph kisspeptin receptor

Y Ma, O Awe, S Radovick, X Yang, S Divall… - Frontiers in …, 2022 - frontiersin.org
The kisspeptin receptor, crucial for hypothalamic control of puberty and reproduction, is also
present in the pituitary gland. Its role in the pituitary gland is not defined. Kisspeptin …