The engulfment of apoptotic cells is of crucial importance for tissue homeostasis in
multicellular organisms. A failure of this process results in secondary necrosis triggering …

Annexins are characterized by the ability to bind phospholipids of membranes in the
presence of Ca2+. Annexin A5 represents a typical member of this protein family and is a …

Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in
membrane organization and the regulation of the immune system. It has been attributed an …

Phagocytic clearance of apoptotic leukocytes plays an important role in the resolution of
inflammation. The glucocorticoid-inducible protein annexin 1 and annexin 1-derived …

Identification and clearance of apoptotic cells prevents the release of harmful cell contents
thereby suppressing inflammation and autoimmune reactions. Highly conserved annexins …

Prevention of an immune response against self-antigens derived from apoptotic cells is
essential to preclude autoimmune and chronic inflammatory diseases. Here, we describe …

Engulfment of apoptotic cells requires presentation of new cell surface ligands by the dying
cells. Using a differential proteomics technology, we identify that annexin I is a caspase …

Apoptotic and necrotic cells expose phosphatidylserine (PS). This membrane modification
ensures a swift recognition and uptake by phagocytes of the dying and dead cells. Annexin …

Proteins of the annexin family bind to phospholipids in a Ca2+ dependent manner. The
exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat …

Apoptotic cell death and the efficient clearance of dying cells are essential mechanisms to
control tissue homeostasis and to eliminate potential autoantigens. Numerous alterations on …