Dynamic m6A mRNA Methylation Reveals the Role of METTL3/14-m6A-MNK2-ERK Signaling Axis in Skeletal Muscle Differentiation and Regeneration

SJ Xie, H Lei, B Yang, LT Diao, JY Liao… - Frontiers in Cell and …, 2021 - frontiersin.org
N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various
biological processes by regulating gene expression. However, the dynamic profile, function …

[HTML][HTML] Regulation of RNA N6-methyladenosine modification and its emerging roles in skeletal muscle development

J Li, Y Pei, R Zhou, Z Tang, Y Yang - International Journal of …, 2021 - ncbi.nlm.nih.gov
Abstract N 6-methyladenosine (m 6 A) is one of the most widespread and highly conserved
chemical modifications in cellular RNAs of eukaryotic genomes. Owing to the development …

METTL3‐Mediated m6A Methylation Regulates Muscle Stem Cells and Muscle Regeneration by Notch Signaling Pathway

Y Liang, H Han, Q Xiong, C Yang, L Wang… - Stem cells …, 2021 - Wiley Online Library
The Pax7+ muscle stem cells (MuSCs) are essential for skeletal muscle homeostasis and
muscle regeneration upon injury, while the molecular mechanisms underlying muscle stem …

Characterization of Long Non-coding RNAs Modified by m6A RNA Methylation in Skeletal Myogenesis

SJ Xie, S Tao, LT Diao, PL Li, WC Chen… - Frontiers in Cell and …, 2021 - frontiersin.org
Proper development of mammalian skeletal muscle relies on precise gene expression
regulation. Our previous studies revealed that muscle development is regulated by both …

METTL3 Promotes the Differentiation of Goat Skeletal Muscle Satellite Cells by Regulating MEF2C mRNA Stability in am6A-Dependent Manner

S Zhao, J Cao, Y Sun, H Zhou, Q Zhu, D Dai… - International journal of …, 2023 - mdpi.com
The development of mammalian skeletal muscle is a highly complex process involving
multiple molecular interactions. As a prevalent RNA modification, N6-methyladenosine …

[HTML][HTML] Longitudinal epitranscriptome profiling reveals the crucial role of N6-methyladenosine methylation in porcine prenatal skeletal muscle development

X Zhang, Y Yao, J Han, Y Yang, Y Chen, Z Tang… - Journal of genetics and …, 2020 - Elsevier
Abstract N 6-methyladenosine (m 6 A) represents the most abundantly occurring mRNA
modification and is involved in the regulation of skeletal muscle development. However, the …

Transcriptome-wide N 6-Methyladenosine Methylome Profiling Reveals m6A Regulation of Skeletal Myoblast Differentiation in Cattle (Bos taurus)

X Yang, J Wang, X Ma, J Du, C Mei… - Frontiers in Cell and …, 2021 - frontiersin.org
N 6-methyladenosine (m6A) is the most prevalent methylation modification of eukaryotic
mRNA, and it plays an important role in regulating gene expression. Previous studies have …

Targeted Demethylation of the TGFβ1 mRNA Promotes Myoblast Proliferation via Activating the SMAD2 Signaling Pathway

K Deng, Z Liu, X Li, Z Zhang, Y Fan, Q Huang, Y Zhang… - Cells, 2023 - mdpi.com
Recent evidence suggested that N6-methyladenosine (m6A) methylation can determine
m6A-modified mRNA fate and play an important role in skeletal muscle development. It was …

Regulation of m6A RNA Methylation and Its Effect on Myogenic Differentiation in Murine Myoblasts

JN Chen, Y Chen, YY Wei, MA Raza, Q Zou, XY Xi… - Molecular Biology, 2019 - Springer
Abstract N 6-methyladenosine (m 6 A) has been identified as a conserved epitranscriptomic
modification of eukaryotic mRNAs, and plays important biological roles in the regulation of …

m6A Methylases Regulate Myoblast Proliferation, Apoptosis and Differentiation

X Yang, C Mei, X Ma, J Du, J Wang, L Zan - Animals, 2022 - mdpi.com
Simple Summary N 6-methyladenosine (m6A) is the most prevalent methylation modification
in eukaryotic mRNA, and it plays an important role in regulating gene expression. Previous …