Hypoxia is a state of low oxygen tension found in numerous solid tumours. It is typically
associated with abnormal vasculature, which results in a reduced supply of oxygen and …

In recent years, there has been great progress in the understanding of tumor biology and its
surrounding microenvironment. Solid tumors create regions with low oxygen levels …

Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …

Hypoxia is a salient feature in many solid tumors and an important player in tumor growth
and progression. Increasing evidence suggests hypoxia plays major roles in the …

Hypoxia is a hallmark of the tumor microenvironment, which promotes the proliferation,
metastasis and invasion of tumors and stimulates the resistance of cancer treatments …

Hypoxia is an important characteristic of most solid malignancies, and is closely related to
tumor prognosis and therapeutic resistance. Hypoxia is one of the most important factors …

Hypoxia, a characteristic feature of tumors, is indispensable to tumor angiogenesis,
metastasis, and multi drug resistance. Hypoxic avascular regions, deeply embedded inside …

Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a
given patient population. It is a negative prognostic and predictive factor owing to its multiple …

Tumour hypoxia has been pursued as a cancer drug target for over 30 years, most notably
using bioreductive (hypoxia-activated) prodrugs that target antineoplastic agents to low …

Tumour hypoxia is a known and extensively researched phenomenon that occurs in both
solid and haematological malignancies. As cancer cells proliferate, demand for oxygen can …