Heterocyclic molecules are well-known drugs against various diseases including cancer.
Many tyrosine kinase inhibitors including erlotinib, osimertinib, and sunitinib were …

Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a crucial role in
the onset and progression of different types of cancers. The existing EGFR-TKD inhibitors …

Epidermal growth factor receptor tyrosine kinase domain (EGFR-TKD) plays a pivotal role in
cellular signaling, growth, and metabolism. The EGFR-TKD is highly expressed in cancer …

Epidermal growth factor receptor (EGFR) family has gained importance as a target for
cancer therapy. However, somatic mutations in the tyrosine kinase domain of EGFR alter its …

Cancer causes innumerable deaths every year globally. Breast cancer and non-small cell
lung carcinoma are the most prevalent worldwide. EGFR-TKD is a neoplastic survival …

Quinazoline derivatives are potent inhibitors of human epidermal growth factor receptor
(EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of …

Cancer is a challenging and second most deadly disease. The epidermal growth factor
receptors (EGFRs) dimerize upon ligand bindings to the extracellular domain that intiates …

In order to show antiproliferation and cancerous cell growth inhibition of quinazoline
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …

A series of novel 4-anilino quinazoline derivatives were taken based on the literature study
and optimized with Autodock version 4.2 and molecular dynamics (MD) protocol to …

Epidermal growth factor receptor (EGFR) is one of the important receptor tyrosine kinases
(RTKs). The thiourea is widely used in drug discovery and development. Therefore, an in …