There has been significant interest in the potential of cytosine–guanine (CpG) containing
oligodeoxynucleotides (ODN) as an immunotherapy for malignant, infectious and allergic …

Innate immune responses recognizing pathogen associated molecular patterns play
important roles in adaptive immunity. As such, ligands which mimic the conserved products …

We have previously demonstrated that the immune response to an unmethylated cytidine–
guanosine (CpG)-containing oligonucleotide (ODN) is greatly enhanced when encapsulated …

Immunostimulatory CpG oligonucleotides (ODN) show promise as immune adjuvants, anti-
allergens, and immunoprotective agents. Increasing the bioavailability and duration of action …

The therapeutic benefit from phosphorothioate oligodeoxynucleotides (PS ODN) containing
immune stimulatory sequences (ISS) has been demonstrated in animal models of cancer …

Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …

Unmethylated cytosine-phosphate-guanosine (CpG) oligodeoxynucleotides (ODNs) are
recognized by Toll-like receptor 9 (TLR9) found in antigen-presenting cells and B cells and …

Cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODN) have shown
significant potential for treatment of a wide variety of diseases including cancer. CpG ODN …

Synthetic oligodeoxynucleotides containing immunostimulatory CpG motif mimic bacterial
DNA and are potent activator of innate and adaptive immune responses. Therefore, CpG …

Abstract Purpose Cationized gelatin nanoparticles (GNPs) were used as carrier to improve
delivery of immunostimulatory CpG oligonucleotides (CpG ODN) both in vitro and in vivo …