Abstract The Look AHEAD (Action for Health in Diabetes) study is a multicenter, randomized
controlled trial designed to determine whether intentional weight loss reduces …

OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular
disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes …

Overweight and obesity are major contributors to both type 2 diabetes and cardiovascular
disease (CVD). Moreover, individuals with type 2 diabetes who are overweight or obese are …

BACKGROUND: Most persons with type 2 diabetes are overweight, and obesity worsens the
metabolic and physiologic abnormalities associated with diabetes. Our objective was to …

Objective To evaluate 8‐year weight losses achieved with intensive lifestyle intervention (ILI)
in the Look AHEAD (Action for Health in Diabetes) study. Design and Methods Look AHEAD …

Aims To provide a systematic review and meta‐analysis of recent evidence on the
effectiveness of lifestyle‐based weight loss interventions for adults with type 2 diabetes …

The majority of people with type 2 diabetes are overweight or obese, and weight loss is a
recommended treatment strategy. A systematic review and meta-analysis was undertaken to …

Given the array of adverse health consequences of obesity, including increased risk for type
2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), the Look AHEAD trial (N …

OBJECTIVE Short-term weight loss improves cardiovascular disease (CVD) risk factors. We
sought to determine the longer-term effects of maintaining weight loss or, conversely …

This report provides a further analysis of the year 4 weight losses in the Look AHEAD (Action
for Health in Diabetes) study and identifies factors associated with long‐term success. A total …