This Topical review considers the misalignment between outcome measures traditionally
reported in animal models of neuropathic pain (For brevity, we will adhere to convention and …

Neuropathic pain remains poorly treated, with most new drugs falling through the
translational gap. The traditional model of bench-to-bedside research has relied on …

Treatment of pain is one of the major challenges in clinical medicine. However, it is often
difficult to evaluate the effect of a treatment, as the many symptoms of the underlying …

Human experimental pain models require standardized stimulation and quantitative
assessment of the evoked responses. This approach can be applied to healthy volunteers …

Neuropathic pain remains an area of considerable unmet clinical need. Research based on
preclinical animal models has failed to deliver truly novel treatment options, questioning the …

Neuropathic pain encompasses a broad range of conditions associated with a lesion or
disease of the peripheral or central somatosensory system and its prevalence in the general …

Publisher Summary This chapter reviews human surrogate models of neuropathic pain that
focus on the mechanisms of symptom generation. A vast array of human surrogate models …

The paper addresses issues related to the clinical relevance of currently employed animal
models of neuropathic pain and our inability to translate clinical symptoms and signs into …

Introduction Animal disease models are predictive for signs seen in disease. They may
rarely mimic all signs in a specific disease in humans with respect to etiology, cause or …

One of the greatest challenges to creating more efficacious medications for pain control has
been the heterogeneity of the “chronic pain condition.” It is now appreciated that distinct …