Challenges in the diagnosis and management of pediatric hemophagocytic lymphohistiocytosis

LC McCarthy, KS Fernandez, R Antony - Clinical pediatrics, 2018 - journals.sagepub.com
Hemophagocytic lymphohistiocytosis (HLH) is a multiorgan syndrome resulting from
defective regulation of inflammation in which excessive activation of macrophages and …

Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment

S Chandrakasan, AH Filipovich - The Journal of pediatrics, 2013 - jpeds.com
Shanmuganathan Chandrakasan, MD, and Alexandra H. Filipovich, MD Hemophagocytic
lymphohistiocytosis (HLH) is a potentially life-threatening disorder characterized by immune …

Hemophagocytic Lymphohistiocytosis

H Major-Monfried, S Friedman, S Moerdler - 2022 - publications.aap.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of extreme, systemic immune
activation characterized by prolonged fever, hepatosplenomegaly, cytopenias, and elevated …

Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management

A Morimoto, Y Nakazawa, E Ishii - Pediatrics International, 2016 - Wiley Online Library
Hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory
syndrome that is classified into primary and secondary HLH. Primary HLH consists of …

An overview of hemophagocytic lymphohistiocytosis

YM Esteban, JLO de Jong, MS Tesher - Pediatric annals, 2017 - journals.healio.com
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by
a dysregulated hyperinflammatory response associated with aberrant activation of …

Clinical features and diagnosis of hemophagocytic lymphohistiocytosis

KL McClain, O Eckstein - UpToDate, 2018 - uptodate.com
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome
of excessive immune activation. It most frequently affects infants from birth to 18 months of …

Hemophagocytic Lymphohistiocytosis in Adolescents and Young Adults: Genetic Predisposition and Secondary Disease

AE Vasco, JA Talano, L Broglie - Medical Clinics, 2024 - medical.theclinics.com
Hemophagocytic lymphohistiocytosis (HLH) is a disorder of impaired immune regulation that
results in extreme hyperinflammation, subsequent tissue infiltration, and multiorgan failure. It …

[HTML][HTML] Paediatric Hemophagocytic Lymphohistiocytosis: A Case Series With a Diverse Spectrum From a Resource-Limited Setting

S Ray, M Kumar, N Mahajan, A Khatri - Cureus, 2023 - ncbi.nlm.nih.gov
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome characterized
by cytokine storms leading to multi-organ dysfunction and is a highly fatal disease. Infectious …

Pediatric hemophagocytic lymphohistiocytosis

SW Canna, RA Marsh - Blood, The Journal of the American …, 2020 - ashpublications.org
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome describing patients with severe
systemic hyperinflammation. Characteristic features include unremitting fever, cytopenias …

Hemophagocytic lymphohistiocytosis

CE Allen, KL McClain - Paediatrics and Child Health, 2008 - Elsevier
Hemophagoytic lymphohistiocytosis (HLH) is a syndrome characterized by inappropriately
activated lymphocytes that produce high concentrations of cytokines. Diagnosing HLH is …