Metastasis is the principal event leading to death in individuals with cancer, yet its molecular
basis is poorly understood 1. To explore the molecular differences between human primary …

More recently, a small set of 17 genes was reported to predict metastatic potential for a
variety of solid tumors2. These findings suggest that most primary tumor cells express a …

Theories of cancer biology have long held that the metastatic process originates with rare
cells within the primary tumor. A new study using expression array analysis has identified a …

When do cancer cells acquire metastatic identity? Recent reports have indicated that the
propensity to metastasize might be hardwired early during tumor development. Now it …

Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality.
To identify genomic alterations that promote brain metastases, we performed whole-exome …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Intratumoral genetic heterogeneity of driver somatic mutations is present in a variety of tumor
types, yet the extent of heterogeneity is variable. We propose that this variation is a reflection …

Metastasis is the primary cause of cancer-related deaths. Although The Cancer Genome
Atlas has sequenced primary tumour types obtained from surgical resections, much less …

Metastases are responsible for the majority of cancer-related deaths. Although genomic
heterogeneity within primary tumors is associated with relapse, heterogeneity among …