As the only cells capable of efficiently resorbing bone, osteoclasts are central mediators of
both normal bone remodeling and pathologies associates with excessive bone resorption …

Coupling during bone remodeling refers to the spatial and temporal coordination of bone
resorption with bone formation. Studies have assessed the subtle interactions between …

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb
large quantities of bone. Therefore, they are frequently the target of therapeutic interventions …

Simple Summary The formation of multinucleated cells is critical for mature osteoclast
generation. For this to happen, mononuclear pre-osteoclasts migrate in proximity to other …

Bone is continually renewed by the “remodeling” process, which occurs asynchronously at
multiple sites throughout the skeleton. During remodeling, osteoclasts resorb a portion of …

Osteoclasts are the exclusive bone-resorbing cells, playing a central role in bone
metabolism, as well as the bone damage that occurs under pathological conditions,. In …

Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have
attempted to reveal the molecular pathways leading to the differentiation and activation of …

Background Bone remodeling relies on the tightly regulated interplay between bone forming
osteoblasts and bone digesting osteoclasts. Several studies have now described the …

In normal, healthy individuals, bone formation is tightly coupled to bone resorption, resulting
in an equilibrium between these two processes. A recent paper (1) reports that genetic …

Osteoclastogenesis is an ongoing rigorous course that includes osteoclast precursors fusion
and bone resorption executed by degradative enzymes. Osteoclastogenesis is controlled by …