Abbreviations: ACCP= American College of Chest Physicians; APACHE= acute physiology
and chronic health evaluation; ILl= interleukin 1; iNOS= inducible nitric oxide synthase; …

Over the last 100 years, huge advances have been made in the field of sepsis in terms of
pathophysiology, epidemiology, diagnosis, monitoring, and therapeutics. Here, we offer our …

This book is designed to provide a comprehensive and state-of-the-art resource for
clinicians who care for patients with sepsis and research scientist alike,. Patients with severe …

Septic shock remains a major cause of morbidity and mortality, especially in the intensive
care setting. A vast array of treatment strategies is under investigation; despite success in …

Sepsis is one of the most common deadly diseases. Despite its remarkable incidence, and
despite the progress which has been made in understanding this complex syndrome, for …

7. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo
R, Bernard GR, Chiche JD, Coopersmith CM, et al. THe third international consensus …

The development of novel therapeutic agents with demonstrable clinical efficacy in septic
patients has proven to be an elusive goal. Despite a biologically plausible therapeutic …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Sepsis continues to be an important cause of morbidity and mortality and is a major medical
challenge to physicians all over the world. As the tenth leading cause of death overall in the …

Over the past 30 years, 2 major factors have led to a perceived need for better definitions. In
particular, the increasing sophistication, at least in high-income countries, of modalities …