Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia
Background Early administration of appropriate antimicrobials has been correlated with a
better prognosis in patients with bacteremia, but the optimum timing of early antibiotic …
better prognosis in patients with bacteremia, but the optimum timing of early antibiotic …
Beneficial effects of early empirical administration of appropriate antimicrobials on survival and defervescence in adults with community-onset bacteremia
Background Bloodstream infections are associated with high morbidity and mortality, both of
which contribute substantially to healthcare costs. The effects of early administration of …
which contribute substantially to healthcare costs. The effects of early administration of …
Factors influencing the implementation of antibiotic de-escalation and impact of this strategy in critically ill patients
L Gonzalez, A Cravoisy, D Barraud, M Conrad, L Nace… - Critical care, 2013 - Springer
Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …
An antimicrobial stewardship program improves antimicrobial treatment by culture site and the quality of antimicrobial prescribing in critically ill patients
Introduction Increasing antimicrobial costs, reduced development of novel antimicrobials,
and growing antimicrobial resistance necessitate judicious use of available agents …
and growing antimicrobial resistance necessitate judicious use of available agents …
Emergency department disposition decisions and associated mortality and costs in ICU patients with suspected infection
Background Following emergency department (ED) assessment, patients with infection may
be directly admitted to the intensive care unit (ICU) or alternatively admitted to hospital …
be directly admitted to the intensive care unit (ICU) or alternatively admitted to hospital …
Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality
J Garnacho-Montero, A Gutiérrez-Pizarraya… - Critical care, 2015 - Springer
Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …
Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units
P Montravers, H Dupont, R Gauzit, B Veber, JP Bedos… - Critical Care, 2011 - Springer
Introduction Few studies have addressed the decision-making process of antibiotic therapy
(AT) in intensive care unit (ICU) patients. Methods In a prospective observational study, all …
(AT) in intensive care unit (ICU) patients. Methods In a prospective observational study, all …
β-lactam antibiotic concentrations during continuous renal replacement therapy
M Beumier, GS Casu, M Hites, L Seyler, F Cotton… - Critical Care, 2014 - Springer
Introduction The use of standard doses of β-lactam antibiotics during continuous renal
replacement therapy (CRRT) may result in inadequate serum concentrations. The aim of this …
replacement therapy (CRRT) may result in inadequate serum concentrations. The aim of this …
Antibiotic prescription patterns in the empiric therapy of severe sepsis: combination of antimicrobials with different mechanisms of action reduces mortality
A Díaz-Martín, ML Martínez-González, R Ferrer… - Critical care, 2012 - Springer
Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …
Initial use of one or two antibiotics for critically ill patients with community-acquired pneumonia: impact on survival and bacterial resistance
C Adrie, C Schwebel, M Garrouste-Orgeas, L Vignoud… - Critical Care, 2013 - Springer
Introduction Several guidelines recommend initial empirical treatment with two antibiotics
instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring …
instead of one to decrease mortality in community-acquired pneumonia (CAP) requiring …