The neural crest is regionalized along the anteroposterior axis, as demonstrated by
foundational lineage-tracing experiments that showed the restricted developmental potential …

The rate of proliferation of cells depends on the proportion of cycling cells and the frequency
of cell division. Here, we describe in detail methods for quantifying the proliferative behavior …

What has made vertebrates so successful has been the evolution of their superior sensory
organs, a more sophisticated organization of the brain, and—eventually—toothed powerful …

The neural crest is a population of migratory cells, arising from the ectoderm, that invades
many sites within the embryo and differentiate into a variety of diverse cell types. Pigment …

Neural crest cell genes control the migration of neural crest cells to multiple parts of
developing vertebrate embryos. A recent hypothesis posits that the “domestication …

The fields of both developmental and stem cell biology explore how functionally distinct cell
types arise from a self-renewing founder population. Multipotent, proliferative human neural …

The neural crest is a transient population of cells that emerges from the neural tube during
the early stages of embryonic development. Neural crest cells are unique to vertebrates and …

The neural crest is a uniquely vertebrate cell type and has been well studied in a number of
model systems. Zebrafish, Xenopus and chick embryos largely show consistent …

Highlights•Genetic tools allow single cell lineage-tracing at high resolution.•Single cell
lineage-tracing demonstrates multipotency of neural crest cells.•Genetic lineage tracing …

Neural crest cells are central to vertebrate development and evolution, endowing
vertebrates with a “new head” that resulted in morphological, physiological, and behavioral …