Approaches to macroevolution require integration of its two fundamental components, ie the
origin and the sorting of variation, in a hierarchical framework. Macroevolution occurs in …

Neural crest cells are a multipotent, migratory cell population that generates an
astonishingly diverse array of cell types during vertebrate development. These include …

Mutations that affect the morphogenetic behaviour and differentiation of neural crest-derived
cells in mouse embryos have been shown to alter genes that code for growth factors or …

Neural crest cells, which are specific to vertebrates, arise in the ectoderm but can generate
cell types that are typically categorized as mesodermal. This broad developmental potential …

The identification of the genes regulating neural progenitor cell (NPC) functions is of great
importance to developmental neuroscience and neural repair. Previously, we combined …

One paramount challenge for neuroscientists over the past century has been to identify the
embryonic origins of the enormous diversity of cortical neurons found in the adult human …

Discovered in chick embryos by Wilhelm His in 1868 and named the neural crest by Arthur
Milnes Marshall in 1879, the neural crest cells that arise from the neural folds have since …

Evolutionary developmental genetics has traditionally been conducted by two groups:
Molecular evolutionists who emphasize divergence between species or higher taxa, and …

A major question in developmental biology is how precursor cells give rise to diverse sets of
differentiated cell types. In most systems, it remains unclear whether the precursors can form …

The evolutionary expansion of the mammalian brain, notably the neocortex, provides a
platform for the higher cognitive abilities that characterize humans. Cortical expansion is …