Since its discovery, endothelium-derived nitric oxide (NO) has become one of the most
intensely investigated molecules in the field of cardiovascular physiology. Although initial …

The vascular endothelium is a monolayer of cells between the vessel lumen and the
vascular smooth muscle cells. Nitric oxide (NO) is a soluble gas continuously synthesized …

▪ Abstract Nitric oxide (NO) is a small, diffusible, lipophilic free radical gas that mediates
significant and diverse signaling functions in nearly every organ system in the body. The …

In 1980, Furchgott and Zawadzki demonstrated that the relaxation of vascular smooth
muscle cells in response to acetylcholine is dependent on the anatomical integrity of the …

▪ Abstract Endothelial nitric oxide synthase (eNOS) is expressed in vascular endothelium,
airway epithelium, and certain other cell types where it generates the key signaling molecule …

The endothelium is a single cell layer that lines all blood vessels. This tissue produces an
impressive array of paracrine factors that maintain vascular homeostasis. One of these …

Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the
field was published only 25 years ago. Nevertheless its impact is such that to date more than …

▪ Abstract The product of nitric oxide (NO) synthase is the most potent endogenous
vasodilator known. NO not only is a potent vasodilator, it also inhibits platelet adherence and …

Atherosclerosis is a chronic inflammatory process in the intima of conduit arteries, which
disturbs the endothelium‐dependent regulation of the vascular tone by the labile liposoluble …

Nitric oxide (NO) is a structurally simple, highly versatile molecule that was originally
discovered over 30 years ago as an endothelium-derived relaxing factor. In addition to its …