Nitric oxide (NO) is a structurally simple, highly versatile molecule that was originally
discovered over 30 years ago as an endothelium-derived relaxing factor. In addition to its …

The endothelium is now recognized not only as a physical barrier between blood and
vascular wall, but also as an important and strategically located organ with multiple …

Nitric oxide produced by three different isoforms of nitric oxide synthase (NOS) widely
expressed in virtually all vascular cell types is mostly produced by the endothelial isoform …

Numerous investigations have indicated that in both health and diseas~ the shortlived
radical nitric oxide (NO) is a key effector in the vascular system (Fig. 1). NO is generated by a …

The endothelial nitric oxide synthase (eNOS), the expression of which is regulated by a
range of transcriptional and posttranscriptional mechanisms, generates nitric oxide (NO) in …

There are few discoveries with the magnitude of the impact that NO has had on biology
during the 25 years since its discovery. There is hardly a disease today not associated with …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium-derived …

The objective of this study was to investigate the regulation of endothelial nitric oxide (NO)
synthase by NO. Partially purified endothelial NO synthase was exposed to authentic NO (10 …

Atherosclerosis and hypercholesterolaemia disturb the endothelium-dependent regulation
of the vascular tone by the labile liposoluble radical nitric oxide. This defect predisposes to …

The endothelium-derived relaxing factor that mediates the endothelium-dependent
vasodilatation first observed in 1980 has been identified as nitric oxide (NO). In addition to …