The endothelium plays an important role in the maintenance of vascular homeostasis.
Central to this role is the endothelial production of nitric oxide (NO), synthesized by the …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

Endothelium derived nitric oxide (NO) plays a major role in cardiovascular homeostasis. It
has important antiatherosclerotic properties which include regulation of vasomotor tone and …

The endothelium, when stimulated by neurotransmitters, hormones, substances derived
from platelets and the coagulation system, can evoke relaxations (Fig. i;[1, 2]). The mediator …

Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

The formation of a neointima represents an important repair mechanism in response to
vascular injury. It is associated with the expression of a specific set of genes by the intimal …

During the past 15 years it has become clear that nitric oxide (NO•) released by endothelial
cells plays a crucial role in vascular homeostasis. In addition to its role as a vasodilator, NO• …

Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to
anti‐proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the …

Angiogenesis requires the elaboration of endothelium-derived nitric oxide (NO). Angiogenic
factors induce the release of NO from endothelial cells, which mediates a multiplicity of …

▪ Abstract Nitric oxide (NO), the biologically active component of endothelium-derived
relaxing factor, has critical roles in the maintenance of vascular homeostasis. Decreased …