Genomic characterization of childhood acute lymphoblastic leukemia

CG Mullighan - Seminars in hematology, 2013 - Elsevier
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading case of childhood cancer death. The last decade has witnessed a transformation in …

Childhood acute lymphoblastic leukemia: Integrating genomics into therapy

SK Tasian, ML Loh, SP Hunger - Cancer, 2015 - Wiley Online Library
Acute lymphoblastic leukemia (ALL), the most common malignancy of childhood, is a
genetically complex entity that remains a major cause of childhood cancer‐related mortality …

Somatic and germline genomics in paediatric acute lymphoblastic leukaemia

CH Pui, KE Nichols, JJ Yang - Nature reviews Clinical oncology, 2019 - nature.com
Advances in genomic research and risk-directed therapy have led to improvements in the
long-term survival and quality of life outcomes of patients with childhood acute lymphoblastic …

Biology of childhood acute lymphoblastic leukemia

LL Nigro - Journal of pediatric hematology/oncology, 2013 - journals.lww.com
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood,
accounting for almost 30% of pediatric cancers. Despite the high rate of cure, ALL is one of …

Global genomic characterization of acute lymphoblastic leukemia

CG Mullighan, JR Downing - Seminars in hematology, 2009 - Elsevier
A key goal in cancer research is to identify the total complement of genetic and epigenetic
alterations that contribute to tumorogenesis. We are currently witnessing the rapid evolution …

Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics

SK Tasian, SP Hunger - British journal of haematology, 2017 - Wiley Online Library
Major advances in genetic and epigenetic profiling of acute lymphoblastic leukaemia (ALL)
have enhanced the understanding of key biological subsets of de novo and relapsed ALL …

The molecular genetic makeup of acute lymphoblastic leukemia

CG Mullighan - Hematology 2010, the American Society of …, 2012 - ashpublications.org
Genomic profiling has transformed our understanding of the genetic basis of acute
lymphoblastic leukemia (ALL). Recent years have seen a shift from microarray analysis and …

Genetics and prognosis of ALL in children vs adults

KG Roberts - Hematology 2014, the American Society of …, 2018 - ashpublications.org
Acute lymphoblastic leukemia (ALL) is characterized by genetic alterations that block
differentiation, promote proliferation of lymphoid precursor cells, and are important for risk …

Genomics in acute lymphoblastic leukaemia: insights and treatment implications

KG Roberts, CG Mullighan - Nature reviews Clinical oncology, 2015 - nature.com
Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

Advances in the biology of acute lymphoblastic leukemia—from genomics to the clinic

CG Mullighan, CL Willman - Journal of adolescent and young adult …, 2011 - liebertpub.com
Despite impressive advances in cure rates for childhood acute lymphoblastic leukemia
(ALL), ALL remains the leading cause of disease-related death in young people and new …