Molecular Mechanisms of N-Acetylcysteine in RSV Infections and Air Pollution-Induced Alterations: A Scoping Review

A Wrotek, A Badyda, T Jackowska - International Journal of Molecular …, 2024 - mdpi.com
N-acetylcysteine (NAC) is a mucolytic agent with antioxidant and anti-inflammatory
properties. The respiratory syncytial virus (RSV) is one of the most important etiological …

N‐Acetyl‐L‐Cysteine Protects Airway Epithelial Cells during Respiratory Syncytial Virus Infection against Mucin Synthesis, Oxidative Stress, and Inflammatory …

L Chi, Y Shan, Z Cui - Analytical Cellular Pathology, 2022 - Wiley Online Library
Objective. Respiratory syncytial virus (RSV) infection is an important cause of hospitalization
of children worldwide, leading to significant morbidity and mortality. RSV infection leads to …

N-acetylcysteine decreases lung inflammation and fibrosis by modulating ROS and Nrf2 in mice model exposed to particulate matter

SM Choi, PH Lee, MH An, L Yun-Gi, S Park… - …, 2022 - Taylor & Francis
Abstract Background and Objectives: Air pollutants can induce and incite airway diseases
such as asthma. N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis …

N-Acetylcysteine: An old drug with variable anti-influenza properties

T Casanova, M Garigliany - Journal of Controversies in Biomedical …, 2016 - jcbmr.com
N-acetylcysteine (NAC) is a mucolytic drug commonly used as an adjuvant therapy in
patients with respiratory conditions associated with excessive mucus production. NAC also …

Advances in the Use of N-Acetylcysteine in Chronic Respiratory Diseases

D Mokra, J Mokry, R Barosova, J Hanusrichterova - Antioxidants, 2023 - mdpi.com
N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the
therapeutic protocols of cystic fibrosis. NAC is also administered as an antidote in …

N-acetyl-L-cysteine (NAC) inhibit mucin synthesis and pro-inflammatory mediators in alveolar type II epithelial cells infected with influenza virus A and B and with …

M Mata, E Morcillo, C Gimeno, J Cortijo - Biochemical pharmacology, 2011 - Elsevier
64% of chronic obstructive pulmonary disease (COPD) exacerbations are caused by
respiratory infections including influenza (strains A and B) and respiratory syncytial virus …

Influence of dose and exposition time in the effectiveness of N-Acetyl-L-cysteine treatment in A549 human epithelial cells

P Montero, I Roger, C Estornut, J Milara, J Cortijo - Heliyon, 2023 - cell.com
Abstract N-Acetyl-l-cysteine (NAC) acts as a precursor of the tripeptide glutathione (GSH),
one of the principal cell mechanisms for reactive oxygen species (ROS) detoxification …

Oxidative stress and viral Infections: rationale, experiences, and perspectives on N-acetylcysteine

P Santus, F Danzo, A Zuffi, S Pini, M Saad… - European Review for …, 2022 - air.unimi.it
This article explores current evidence on the role of oxidative stress in viral infections, and
on the use of antioxidant drugs as adjunctive treatment. MEDLINE/PubMed was searched …

The effects of N-acetylcysteine on lung alveolar epithelial cells infected with respiratory syncytial virus

KK Wong, KP Kua, KS Ooi… - The Malaysian Journal of …, 2023 - search.proquest.com
Keywords: A549 cells, alveolar epithelial cell, cytotoxicity, N-acetylcysteine, RSV infection
INTRODUCTION Respiratory syncytial virus (RSV; genus Orthopneumovirus, family …

Redox paradox: effect of N-acetylcysteine and serum on oxidation reduction–sensitive mitogen-activated protein kinase signaling pathways

ED Chan, DWH Riches, CW White - American journal of respiratory …, 2001 - atsjournals.org
The thiol reducing agent N-acetylcysteine (NAC) is commonly used as an “antioxidant” in
studies examining gene expression, signaling pathways, and outcome in acute and chronic …