Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates cell death by
interrupting classic pathways of apoptosis. Intracerebral hemorrhage (ICH) is a devastating …

Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid, is a strong modulator of
apoptosis in both hepatic and nonhepatic cells, and appears to function by inhibiting …

Traumatic brain injury (TBI) is one of the leading causes of trauma-induced mortality and
disability, and emerging studies have shown that endoplasmic reticulum (ER) stress plays …

Background Bile acids are steroid acids found predominantly in the bile of mammals. The
bile acid conjugate tauroursodeoxycholic acid (TUDCA) is a neuroprotective agent in …

Tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates cell death by
interrupting classic pathways of apoptosis. Amyloid-β (Aβ) peptide has been implicated in …

Most neurodegenerative disorders are diseases of protein homeostasis, with misfolded
aggregates accumulating. The neurodegenerative process is mediated by numerous …

Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …

Background/Aims: Unconjugated bilirubin (UCB) can be neurotoxic in jaundiced neonates
and in patients with Crigler–Najjar syndrome. UCB toxicity may culminate in cell death …

Bile acids are a group of molecular species of acidic steroids with peculiar physical-
chemical and biological characteristics. At high concentrations they become toxic to …

The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense
research in recent years. Ursodeoxycholic acid (UDCA) and its taurine-conjugate …