Mechanisms and context underlying the role of autophagy in cancer metastasis

CM Dower, CA Wills, SM Frisch, HG Wang - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a fundamental cellular degradation mechanism that
maintains cell homeostasis, regulates cell signaling, and promotes cell survival. Its role in …

Autophagy in cancer metastasis

EE Mowers, MN Sharifi, KF Macleod - Oncogene, 2017 - nature.com
Autophagy is a highly conserved self-degradative process that has a key role in cellular
stress responses and survival. Recent work has begun to explore the function of autophagy …

The double-edged sword of autophagy modulation in cancer

E White, RS DiPaola - Clinical cancer research, 2009 - AACR
Macroautophagy (autophagy) is a lysosomal degradation pathway for the breakdown of
intracellular proteins and organelles. Although constitutive autophagy is a homeostatic …

Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

Functions of autophagy in the tumor microenvironment and cancer metastasis

EE Mowers, MN Sharifi, KF Macleod - The FEBS journal, 2018 - Wiley Online Library
Macro‐autophagy is an ancient and highly conserved self‐degradative process that plays a
homeostatic role in normal cells by eliminating organelles, pathogens, and protein …

The evolving, multifaceted roles of autophagy in cancer

J Liu, J Debnath - Advances in cancer research, 2016 - Elsevier
Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …

Autophagy as a therapeutic target in cancer

N Chen, V Karantza - Cancer biology & therapy, 2011 - Taylor & Francis
Autophagy is a self-catabolic process that maintains intracellular homeostasis and prolongs
cell survival under stress via lysosomal degradation of cytoplasmic constituents and …

Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer

CK Das, I Banerjee, M Mandal - Seminars in Cancer Biology, 2020 - Elsevier
Autophagy is an evolutionary conserved catabolic process that regulates the cellular
homeostasis by targeting damaged cellular contents and organelles for lysosomal …

Molecular mechanisms of autophagy in cancer development, progression, and therapy

VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

Molecular pathways: autophagy in cancer—a matter of timing and context

M Cicchini, V Karantza, B Xia - Clinical cancer research, 2015 - AACR
Autophagy is an intracellular self-digestion mechanism, by which cellular components are
sorted into double-membrane autophagosomes and delivered to lysosomes for degradation …