TrkB belongs to the Trk family of tyrosine kinase receptors and mediates the response to
brain‐derived neurotrophic factor (BDNF) and neurotrophin‐4/5 (NT‐4/5). Here, we report …

trkB encodes a receptor tyrosine kinase activated by three neurotrophins—brain-derived
neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4/5. In vivo, three isoforms of …

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival
through activation of TrkB receptors. The trkB gene encodes a full-length receptor tyrosine …

The receptor tyrosine kinase TrkB and its ligands, brain-derived neurotrophic factor (BDNF)
and neurotrophin-4/5 (NT-4/5), are critically important for growth, survival and activity …

Chronic exposure of brain neurons to nerve growth factor in vitro and in vivo results in
increased levels of the nerve growth factor receptor TrkA. In contrast, in the present study …

Neurotrophin signaling via receptor tyrosine kinases is essential for the development and
function of the nervous system in vertebrates. TrkB activation and signaling show substantial …

A family of tyrosine receptor kinases known collectively as trk receptors plays an essential
role in signal transduction mediated by nerve growth factor and related neurotrophins. To …

The trkB family of transmembrane proteins serves as receptors for BDNF and NT-4/5. The
family is composed of a tyrosine kinase-containing isoform as well as several alternatively …

Brain-derived neurotrophic factor (BDNF) signaling through its receptor, TrkB, modulates
survival, differentiation, and synaptic activity of neurons. Both full-length TrkB (TrkB-FL) and …

This study examines the mechanisms by which the tyrosine kinase receptor TrkB is down-
regulated following binding of brain-derived neurotrophic factor (BDNF). In primary cultures …