Tissue hypoxia has been proposed as an important event in renal ischemia-reperfusion
injury (IRI), particularly during the period of ischemia and in the immediate hours following …

Acute kidney injury (AKI) is a significant clinical problem associated with poor outcome. The
kidney, due to its inhomogeneous blood flow, is particularly susceptible to changes in …

Tissue hypoxia has been demonstrated, in both the renal cortex and medulla, during the
acute phase of reperfusion after ischemia induced by occlusion of the aorta upstream from …

Ischemic acute renal failure (ARF) results in the permanent loss of peritubular capillaries
and predisposes the progression of chronic renal failure. The present study was undertaken …

Background: We hypothesized that chronic renal parenchymal disease may predispose to
acute renal failure (ARF), facilitating the induction of hypoxic medullary tubular injury …

Ischemia is the most common cause of acute renal failure. Ischemic-induced renal tissue
hypoxia is thought to be a major component in the development of acute renal failure in …

The pathogenesis of acute kidney injury (AKI), formally termed acute tubular necrosis, is
complex and, phenotypically, may range from functional dysregulation without overt …

Imbalance between renal oxygen delivery and demand in the first hours after reperfusion is
suggested to be decisive in the pathophysiological chain of events leading to ischemia …

Abstract Models of ischemic acute renal failure (ARF) must consider the combination of
tissue hypoxia, insufficient nutrient flow, and anaerobic waste product accumulation. This …

The purpose of this study is to confirm previous evidence for reactive oxygen species (ROS)
as critical mediators of postischemic renal injury by documenting lipid peroxidation after …