Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis
X Kang, K Zhang, Y Wang, Y Zhao, Y Lu - Frontiers in cell and …, 2023 - frontiersin.org
Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative
articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence …
articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence …
Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis
W Hu, Y Chen, C Dou, S Dong - Annals of the Rheumatic Diseases, 2021 - ard.bmj.com
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …
considered as primarily a disease of the articular cartilage, the participation of subchondral …
Emerging targets in osteoarthritis therapy
MB Goldring, F Berenbaum - Current opinion in pharmacology, 2015 - Elsevier
Highlights•Different OA etiologies present a challenge for developing a single targeted
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
therapy.•Common mechanisms occur in inflammatory, mechanical, and oxidative stress in …
[PDF][PDF] The role of the chondrocyte in osteoarthritis
MB Goldring - Arthritis & Rheumatism: Official Journal of the …, 2000 - academia.edu
Osteoarthritis (OA) is a slowly progressive degenerative disease characterized by gradual
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …
loss of articular cartilage. Since the OA lesion is often localized to weight-bearing cartilage …
[PDF][PDF] Future directions for research and treatment of osteoarthritis
CJ Malemud, VM Goldberg - Front Biosci, 1999 - article.imrpress.com
[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …
Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: role of integrinβ1 and focal adhesion kinase signaling cues
Introduction Our recent study indicated that subchondral bone pathogenesis in osteoarthritis
(OA) is associated with osteocyte morphology and phenotypic abnormalities. However, the …
(OA) is associated with osteocyte morphology and phenotypic abnormalities. However, the …
[HTML][HTML] In vitro inflammatory multi-cellular model of osteoarthritis
I Marrero-Berrios, SE Salter, R Hirday… - … and Cartilage Open, 2024 - Elsevier
Objective Osteoarthritis (OA) is a chronic joint disease, with limited treatment options,
characterized by inflammation and matrix degradation, and resulting in severe pain or …
characterized by inflammation and matrix degradation, and resulting in severe pain or …
Developments in the synovial biology field 2006
A Knedla, E Neumann, U Müller-Ladner - Arthritis research & therapy, 2007 - Springer
Synovial pathophysiology is a complex and synergistic interplay of different cell populations
with tissue components, mediated by a variety of signaling mechanisms. All of these …
with tissue components, mediated by a variety of signaling mechanisms. All of these …
Cross-talk of subchondral bone osteoblasts and articular cartilage chondrocytes: a new insight in understanding osteoarthritis pathogenesis
I Prasadam - 2009 - eprints.qut.edu.au
Osteoarthritis (OA) is the most common musculoskeletal disorder and represents a major
health burden to society. In the course of the pathological development of OA, articular …
health burden to society. In the course of the pathological development of OA, articular …