[HTML][HTML] Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee

S Jang, K Lee, JH Ju - International journal of molecular sciences, 2021 - mdpi.com
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical
symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain …

Challenges in osteoarthritis treatment

A Emami, H Namdari, F Parvizpour, Z Arabpour - Tissue and cell, 2023 - Elsevier
Osteoarthritis (OA) is the most common form of arthritis and a degenerative joint cartilage
disease that is the most common cause of disability in the world among the elderly. It leads …

From osteoarthritis treatments to future regenerative therapies for cartilage

J Clouet, C Vinatier, C Merceron, M Pot-vaucel… - Drug discovery today, 2009 - Elsevier
Osteoarthritis (OA) is associated with cartilage degeneration and an accompanying
inflammatory syndrome of the synovium in addition to alteration of the subchondral bone …

[引用][C] Osteoarthritis at the cellular level: mechanisms, clinical perspectives, and insights from development

M Fisher, T Ackley, K Richard, B Oei, CN Dealy - 2019 - Elsevier

Phenotypic modulation of chondrocytes as a potential therapeutic target in osteoarthritis: a hypothesis

T Aigner, J Dudhia - Annals of the rheumatic diseases, 1997 - ard.bmj.com
One central hallmark of osteoarthritic cartilage degeneration is the loss of matrix molecules,
in particular proteoglycans. However, chondrocytes of osteoarthritic cartilage are generally …

[HTML][HTML] Developments in the scientific understanding of rheumatoid arthritis

JJ Goronzy, CM Weyand - Arthritis research & therapy, 2009 - Springer
Rheumatoid arthritis (RA) is recognized to be an autoimmune disease that causes
preclinical systemic abnormalities and eventually leads to synovial inflammation and …

Identification of chondrocyte subpopulations in osteoarthritis using single-cell sequencing analysis

H Gao, J Di, M Yin, T He, D Wu, Z Chen, S Li, L He… - Gene, 2023 - Elsevier
Osteoarthritis (OA) is the most common joint disease. Previous studies were focused on
general functions of chondrocyte population in OA without elucidating the existence of …

Targeting the synovial tissue for treating osteoarthritis (OA): where is the evidence?

M Attur, J Samuels, S Krasnokutsky… - Best Practice & Research …, 2010 - Elsevier
Osteoarthritis (OA) is often a progressive and disabling disease, which occurs in the setting
of a variety of risk factors–such as advancing age, obesity and trauma–that collude to incite …

[HTML][HTML] Current concepts in the pathogenesis of osteoarthritis

S Krasnokutsky, M Attur, G Palmer, J Samuels… - Osteoarthritis and …, 2008 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis

C Huang, B Zeng, B Zhou, G Chen, Q Zhang, W Hou… - Genes & …, 2024 - Elsevier
Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of
chondrocytes in human articular cartilage is still not well defined, which hinders our …