Chondrocyte is considered the only cell type in cartilage. However, the cell heterogeneity of
chondrocytes in human articular cartilage is still not well defined, which hinders our …

Targeting signaling pathways in osteoarthritis did not seem feasible a few years ago
because of the complexity of the multiple intracellular pathways, mainly physiologic, defined …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

The view of articular cartilage as a non-regeneration organ has been challenged in recent
years. The articular cartilage consists of distinct zones with different cellular and molecular …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …

Osteoarthritis (OA) is a disease in which the pathogenesis affects the joint and its
surrounding tissues. Cartilage degeneration is the main hallmark of OA, and chondrocytes …

Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA).
The resulting joint destruction constitutes one of the major disease consequences for …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

Mechanical joint loading is an essential factor in joint homeostasis but it is also the most
important aetiological factor in the development of osteoarthritis (OA). Although OA has long …