Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Spinal cord injury results in acute as well as progressive secondary destruction of local and
distant nervous tissue through a number of degenerative mechanisms. Spinal cord injury …

Deficits in neuronal function are a hallmark of spinal cord injury (SCI) and therapeutic efforts
are often focused on central nervous system (CNS) axon regeneration. However, secondary …

Chondroitin sulfate proteoglycans are the principal inhibitory component of glial scars, which
form after damage to the adult central nervous system and act as a barrier to regenerating …

Background context: Recent advances in neuroscience have opened the door for hope
toward prevention and cure of the devastating effects of spinal cord injury (SCI). Purpose: To …

Severe spinal cord injury (SCI) leads to devastating loss of neurological function below the
level of injury and adversely affects multiple body systems. Most basic research on SCI is …

The extracellular environment of the central nervous system (CNS) becomes highly
structured and organized as the nervous system matures. The extracellular space of the …

Spinal cord injury (SCI) often induces loss of motor and/or sensory function below the level
of injury. While deficits persist in complete lesions, partial lesions of the spinal cord can be …

One of the big challenges in neuroscience that remains to be understood is why the central
nervous system is not able to regenerate to the extent that the peripheral nervous system …