Proteins of the Src homology and collagen (Shc) family are typically involved in signal
transduction events involving Ras/MAPK and PI3K/Akt pathways. In the nervous system …

Neurotrophins, such as nerve growth factor and brain-derived neurotrophic factor, activate
Trk receptor tyrosine kinases through receptor dimerization at the cell surface followed by …

Glial cell line derived neurotrophic factor (GDNF) signals through a multicomponent receptor
complex consisting of RET receptor tyrosine kinase and a member of GDNF family receptor …

Activation of the neurotrophin Trk receptors is a key process in the survival and development
of the nervous system. The signaling adapters ShcB and ShcC, but not ShcA, are thought to …

We demonstrate that the signaling adapter, Grb2, binds directly to the neurotrophin receptor
tyrosine kinase, TrkA. Grb2 binding to TrkA is independent of Shc, FRS-2, phospholipase Cγ …

RET receptor signalling is essential for glial-cell-line-derived neurotrophic factor (GDNF)-
induced survival and differentiation of various neurons such as mesencephalic neurons. To …

The signaling mechanisms by which neurotrophic receptors regulate neuronal survival and
axonal growth are still incompletely understood. In the receptor tyrosine kinase RET, a …

The neurotrophin receptor tyrosine kinase TrkB is critical to diverse biological processes. We
investigated the interplay of Src family kinases (SFKs) and TrkB to better understand …

Preliminary screening data showed that the ShcD adaptor protein associates with the proto-
oncogene RET receptor tyrosine kinase. In the present study, we aimed to investigate the …

The RET receptor tyrosine kinase is important for several different biological functions during
development. The recruitment at the phosphorylated Tyr 1062 site in RET of a number of …