CXCR3 is a chemokine receptor preferentially expressed on lymphocytes, particularly on
type-1 T-lymphocytes. Smokers who develop chronic obstructive pulmonary disease …

Activation of the chemokine receptor CXCR3 by its cognate ligands induces several
differentiated cellular responses important to the growth and migration of a variety of …

Background Chemokine receptors (CR) play an important role in T cell migration, but their
contribution to lung trafficking is unclear. Objective We hypothesized that if a particular CR …

Chronic obstructive pulmonary disease (COPD) patients exhibit chronic inflammation, both
in the lung parenchyma and the airways, which is characterised by an increased infiltration …

We recently demonstrated that human bronchial epithelial cells (HBEC) constitutively
express the CXC chemokine receptor CXCR3, which when activated, induces directed cell …

The chemokine CXCL10 is produced by many inflammatory cells found in the diseased lung
and has been implicated in the pathogenesis of chronic obstructive pulmonary disease …

Chemokines have long been implicated in the initiation and amplification of inflammatory
responses by virtue of their role in leukocyte chemotaxis. The expression of one of the …

Background COPD is associated with increased numbers of CD4+ and CD8+ lymphocytes
and macrophages in the small airways and lung parenchyma. The chemokines regulating T …

Background: Increased numbers of activated neutrophils have been reported in the
bronchial mucosa of patients with stable chronic obstructive pulmonary disease (COPD) …

The attraction of T lymphocytes into the pulmonary parenchyma represents an essential step
in mechanisms ultimately leading to lung allograft rejection. In this study we evaluated …