This paper reviews the contribution of chemotherapy in the conquest of osteosarcoma. It
discusses how the treatment of osteosarcoma has evolved over the last five decades …

Opinion statement Improving cure rates for osteosarcoma continues to be a major challenge.
The clinical management of individual patients is exacting and requires a skilled …

The current management of osteosarcoma (OS) is critically reviewed and a modified
treatment strategy is put forward for discussion. The overall treatment results in high-grade …

Osteosarcoma is the most common primary tumor of bone. Approximately 2/3 of patients
who present with localized osteosarcoma can be expected to be cured of their disease with …

Introduction: In the early seventies chemotherapy significantly improved survival in
osteosarcoma. Since then minor innovations have occurred although recent years have …

Despite significant advancements in the diagnosis and treatment of osteosarcoma to date,
overall survival has remained relatively constant for over 2 decades. The challenge in …

Patients who develop osteosarcoma in 2017 receive treatment that remains essentially
unchanged since the 1970s. Outcomes likewise remain largely unimproved. Large …

Introduction: Current treatment of osteosarcoma includes surgical resection of all gross
disease in conjunction with systemic chemotherapy to control micro-metastatic disease. This …

Introduction: Although chemotherapy is currently indispensable for the treatment of
osteosarcoma, chemotherapy for this rare cancer has not been developed based on …

Osteosarcoma is the most common primary bone tumor in childhood and adolescence. The
use of combination chemotherapy and surgery enables long-term survival in approximately …