Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges

C Zoccali, A Ortiz, IA Blumbyte, S Rudolf… - Nephrology Dialysis …, 2022 - academic.oup.com
Neuropeptide Y (NPY) is a 36-amino-acid peptide member of a family also including peptide
YY and pancreatic polypeptide, which are all ligands to Gi/Go coupled receptors. NPY …

Neuropeptide Y and chronic kidney disease progression: a cohort study

C Zoccali, G D'arrigo, D Leonardis… - Nephrology Dialysis …, 2018 - academic.oup.com
ABSTRACT Background Neuropeptide Y (NPY) is a sympathetic neurotransmitter that has
been implicated in various disorders including obesity, gastrointestinal and cardiovascular …

Role of neuropeptide Y in the regulation of kidney function

J Winaver, Z Abassi - NPY family of peptides in neurobiology …, 2006 - Springer
Neuropeptide Y (NPY), a 36-residue peptide is a sympathetic co-transmitter stored and
released together with noradrenaline by adrenergic nerve terminals of the sympathetic …

Neuropeptide Y predicts cardiovascular events in chronic kidney disease patients: a cohort study

C Zoccali, G D'Arrigo, D Leonardis, P Pizzini… - Journal of …, 2019 - journals.lww.com
Background: Neuropeptide Y (NPY) is a multifaceted sympathetic neurotransmitter
regulating reflex cardiovascular control, myocardial cell growth, inflammation and innate …

Prospective study of neuropeptide y as an adverse cardiovascular risk factor in end-stage renal disease

C Zoccali, F Mallamaci, G Tripepi… - Journal of the …, 2003 - journals.lww.com
Chronic renal insufficiency is a situation characterized by high plasma concentration of
neuropeptide Y (NPY). Because this neuropeptide interferes with cardiovascular (CV) …

Neuropeptide Y gene polymorphisms and chronic kidney disease progression

B Spoto, F Mallamaci, C Politi… - Journal of …, 2024 - journals.lww.com
Background: Neuropeptide Y (NPY) is a neurotransmitter expressed in both the central and
peripheral nervous systems, which is involved in regulating a multitude of physiological …

Neuropeptide Y levels are associated with nutritional status and cardiovascular events in adults with chronic kidney disease

L Lu, YC Zou, M Wang, YF Huang, DX Chen… - European Journal of …, 2015 - nature.com
Results: CSF NpY levels and nutritional indices were related during CKD progression
(energy intake: β= 0.236, P< 0.001; mid-arm muscle circumference: β= 0.953, P= 0.014; …

Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes

K McDowell, C Adamson, C Jackson… - European Journal of …, 2024 - Wiley Online Library
Abstract Aims Neuropeptide Y (NPY) is the most abundant neuropeptide found in the heart
and is released alongside norepinephrine following prolonged sympathetic activation, a …

Cross talk about the role of Neuropeptide Y in CNS disorders and diseases

R Bale, G Doshi - Neuropeptides, 2023 - Elsevier
A peptide composed of a 36 amino acid called Neuropeptide Y (NPY) is employed in a
variety of physiological processes to manage and treat conditions affecting the endocrine …

Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases.

J Pons, EW Lee, L Li, J Kitlinska - Current opinion in investigational …, 2004 - europepmc.org
Neuropeptide Y (NPY), a sympathetic co-transmitter, acts through multiple G protein-coupled
receptors (Y1 to y6) to elicit its vast range of effects in the cardiovascular, immune, and …