Pathological ventricular remodeling: mechanisms: part 1 of 2
Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
rehospitalization rates remain distressingly high, substantially affecting individuals, society …
A review of the molecular mechanisms underlying the development and progression of cardiac remodeling
L Schirone, M Forte, S Palmerio, D Yee… - Oxidative medicine …, 2017 - Wiley Online Library
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
the existing structure of the heart, leading to cardiac dysfunction. Among the complex …
Novel pharmacotherapies to abrogate postinfarction ventricular remodeling
GW Dorn - Nature Reviews Cardiology, 2009 - nature.com
Ventricular remodeling after myocardial infarction is defined as progressive chamber dilation
and wall thinning, which leads to functional compromise. Remodeling is mediated by active …
and wall thinning, which leads to functional compromise. Remodeling is mediated by active …
In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
AM Shah, DL Mann - The Lancet, 2011 - thelancet.com
Chronic heart failure continues to impose a substantial health-care burden, despite recent
treatment advances. The key pathophysiological process that ultimately leads to chronic …
treatment advances. The key pathophysiological process that ultimately leads to chronic …
Mechanisms contributing to cardiac remodelling
QQ Wu, Y Xiao, Y Yuan, ZG Ma, HH Liao, C Liu… - Clinical …, 2017 - portlandpress.com
Cardiac remodelling is classified as physiological (in response to growth, exercise and
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …
pregnancy) or pathological (in response to inflammation, ischaemia, ischaemia/reperfusion …
Left ventricular remodeling in the post-infarction heart: a review of cellular, molecular mechanisms, and therapeutic modalities
JJ Gajarsa, RA Kloner - Heart failure reviews, 2011 - Springer
As more patients survive myocardial infarctions, the incidence of heart failure increases.
After an infarction, the human heart undergoes a series of structural changes, which are …
After an infarction, the human heart undergoes a series of structural changes, which are …
Left ventricular remodeling after myocardial infarction: from physiopathology to treatment
Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …
incidence relatively high in developed countries and rapidly growing in developing …
Signaling effectors underlying pathologic growth and remodeling of the heart
JH Van Berlo, M Maillet… - The Journal of clinical …, 2013 - Am Soc Clin Investig
Cardiovascular disease is the number one cause of mortality in the Western world. The heart
responds to many cardiopathological conditions with hypertrophic growth by enlarging …
responds to many cardiopathological conditions with hypertrophic growth by enlarging …
Molecular pathways underlying cardiac remodeling during pathophysiological stimulation
I Kehat, JD Molkentin - Circulation, 2010 - Am Heart Assoc
Cardiac remodeling involves molecular, cellular, and in-terstitial changes that manifest
clinically as changes in size, shape, and function of the heart after injury or stress …
clinically as changes in size, shape, and function of the heart after injury or stress …
New targets to treat the structural remodeling of the myocardium
A González, S Ravassa, J Beaumont, B López… - Journal of the American …, 2011 - jacc.org
Classical therapy of heart failure is based on treatment of its pre-disposing/triggering factors
and of the neurohumoral activation secondary to the deterioration of cardiac function. A new …
and of the neurohumoral activation secondary to the deterioration of cardiac function. A new …