Altitude acclimatization via hypoxia-mediated oxidative eustress involves interplay of protein nitrosylation and carbonylation: A redoxomics perspective
Aim Hypoxia is an important feature of multiple diseases like cancer and obesity and also an
environmental stressor to high altitude travelers. Emerging research suggests the …
environmental stressor to high altitude travelers. Emerging research suggests the …
Oxidative stress, ROS generation, and associated molecular alterations in high altitude hypoxia
High altitude especially above 3000 m of elevation is considered a potential risk for rapid
ascent, while at elevation above 5500 m, it poses life threatening risk to non-adapted …
ascent, while at elevation above 5500 m, it poses life threatening risk to non-adapted …
High-altitude hypoxia induced reactive oxygen species generation, signaling, and mitigation approaches
Homeostasis between pro-oxidants and anti-oxidants is necessary for aerobic life, which if
perturbed and shifted towards pro-oxidants results in oxidative stress. It is generally agreed …
perturbed and shifted towards pro-oxidants results in oxidative stress. It is generally agreed …
[HTML][HTML] STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO2 gradient
Hypobaric hypoxia elicits several patho-physiological manifestations, some of which are
known to be lethal. Among various molecular mechanisms proposed so far, perturbation in …
known to be lethal. Among various molecular mechanisms proposed so far, perturbation in …
Competing trends of ROS and RNS-mediated protein modifications during hypoxia as an alternate mechanism of NO benefits
Hypoxia, especially altitude associated hypoxia is known to cause severe physiological
alterations and life-threatening conditions. Impaired redox balance along with oxidative …
alterations and life-threatening conditions. Impaired redox balance along with oxidative …
[引用][C] Oxidative eustress: the physiological role of oxidants
H Sies - Science China Life Sciences, 2023 - Springer
The perception of a pivotal role of reactive oxygen species (ROS)(Sies et al., 2022), reactive
nitrogen species (RNS) and electrophiles (Parvez et al., 2018) in cell biology and physiology …
nitrogen species (RNS) and electrophiles (Parvez et al., 2018) in cell biology and physiology …
Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure
C Leveque, S Mrakic Sposta, S Theunissen… - International journal of …, 2023 - mdpi.com
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of
10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 …
10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 …
Hypoxia-induced oxidative stress modulation with physical activity
Increased oxidative stress, defined as an imbalance between prooxidants and antioxidants,
resulting in molecular damage and disruption of redox signaling, is associated with …
resulting in molecular damage and disruption of redox signaling, is associated with …
Pulsed hyperoxia acts on plasmatic advanced glycation end products and advanced oxidation protein products and modulates mitochondrial biogenesis in human …
The “normobaric oxygen paradox”(NOP) describes the response to the return to normoxia
after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox …
after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox …
Integration of quantitative proteomics and metabolomics reveals tissue hypoxia mechanisms in an ischemic-hypoxic rat model
R He, Y Kong, P Fang, L Li, H Shi, Z Liu - Journal of proteomics, 2020 - Elsevier
Tissues hypoxia caused by hemorrhage is a common complication in many clinical
diseases. However, its pathological mechanism remains largely unknown. To partly address …
diseases. However, its pathological mechanism remains largely unknown. To partly address …