Ebola viruses are highly lethal human pathogens that have received considerable attention
in recent years due to an increasing re-emergence in Central Africa and a potential for use …

Ebola virus (EBOV) is a significant human pathogen that presents a public health concern as
an emerging/re-emerging virus and as a potential biological weapon. Substantial progress …

Background The worst Ebola virus disease (EVD) outbreak in history has resulted in more
than 28,000 cases and 11,000 deaths. We present the final results of two phase 1 trials of an …

The devastating Ebola virus (EBOV) epidemic in West Africa in 2013–2016 accelerated the
progress of several vaccines and antivirals through clinical trials, including the replication …

Background The Ebola virus is transmitted by direct contact with bodily fluids of infected
individuals, eliciting death rates as high as 90% among infected humans. Currently …

Ebola virus (EBOV) infections cause lethal hemorrhagic fever in humans, resulting in up to
90% mortality. EBOV outbreaks are sporadic and unpredictable in nature; therefore, a …

Introduction: Ebolaviruses cause severe viral hemorrhagic fever in humans and non-human
primates (NHPs), with case fatality rates of up to 90%. Currently, neither a specific treatment …

Ebola viruses cause hemorrhagic disease in humans and nonhuman primates with high
fatality rates. These viruses pose a significant health concern worldwide due to the lack of …

Background. In humans and nonhuman primates, Ebola virus causes a virulent viral
hemorrhagic fever for which no licensed vaccines or therapeutic drugs exist. In the present …

The ongoing outbreak of Ebola virus disease in West Africa highlighted the lack of a
licensed drug or vaccine to combat the disease and has renewed the urgency to develop a …