[HTML][HTML] Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease

Q Song, S Peng, X Zhu - Neurotoxicology, 2021 - Elsevier
Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi,
has neuroprotective properties in several neurological disorders. Many studies suggest that …

Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease

J Huang, X Zhang, X Yang, Q Yv, F Ye, S Chen… - Chemico-Biological …, 2024 - Elsevier
Baicalin, a potent anti-oxidative and anti-inflammatory flavonoid compound derived from
Scutellaria baicalensis, has emerged as a neuroprotective agent. However, the mechanisms …

Baicalein exerts anti-neuroinflammatory effects to protect against rotenone-induced brain injury in rats

X Zhang, Y Yang, L Du, W Zhang, G Du - International …, 2017 - Elsevier
Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi,
has been shown to be neuroprotective in several Parkinson's disease (PD) animal models …

[HTML][HTML] Tectorigenin attenuates the MPP+‑induced SH‑SY5Y cell damage, indicating a potential beneficial role in Parkinson's disease by oxidative stress inhibition

P Gong, F Deng, W Zhang, J Ji… - Experimental and …, 2017 - spandidos-publications.com
Tectorigenin is a plant isoflavonoid primarily derived from the flowers of Pueraria thomsonii
Benth. Although various biological properties of tectorigenin have been reported, such as its …

Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice

X Mu, GR He, X Yuan, XX Li, GH Du - Pharmacology Biochemistry and …, 2011 - Elsevier
Many studies of Parkinson's disease suggest that oxidative stress is involved in the
neurodegenerative process. Baicalein has been shown to have antioxidant effects. The …

Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways

Z Zhang, W Cui, G Li, S Yuan, D Xu… - Journal of Agricultural …, 2012 - ACS Publications
Baicalein, one of the major flavonoids found in Scutellaria baicalensis Georgi, displays
neuroprotective effects on experimental models of Parkinson's disease (PD) in vitro and in …

Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism

X Li, J Zhang, X Zhang, M Dong - Food and Chemical Toxicology, 2020 - Elsevier
In this study, we hypothesized that anti-parkinsonian effect of puerarin is attributable to its
antioxidant properties via Nrf2-dependent glutathione (GSH) biosynthesis mechanism …

Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile

Y Cheng, G He, X Mu, T Zhang, X Li, J Hu, B Xu… - Neuroscience …, 2008 - Elsevier
1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) causes the damage of dopaminergic
neurons as seen in Parkinson's disease (PD). Oxidative stress has been implicated in the …

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23. 5 cells

K Zhang, ZG Ma, J Wang, AM Xie, JX Xie - Neuropharmacology, 2011 - Elsevier
Increasing evidence suggests that oxidative stress may be implicated in the degeneration of
dopaminergic neurons in Parkinson's disease (PD), and anti-oxidation have been shown to …

[HTML][HTML] Preclinical evidence and possible mechanisms of baicalein for rats and mice with Parkinson's disease: A systematic review and meta-analysis

Y Wang, N Wei, X Li - Frontiers in Aging Neuroscience, 2020 - frontiersin.org
Baicalein, a major bioactive flavone of Scutellaria baicalensis Georgi, has neuroprotective
properties in several animal models of Parkinson's disease (PD). Here, we conducted a …