Abstract Analysis of molecular aberrations across multiple cancer types, known as pan-
cancer analysis, identifies commonalities and differences in key biological processes that …

Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …

The cancer genome is moulded by the dual processes of somatic mutation and selection.
Homozygous deletions in cancer genomes occur over recessive cancer genes, where they …

Highly rearranged and mutated cancer genomes present major challenges in the
identification of pathogenetic events driving the neoplastic transformation process. Here we …

Many studies have shown that primary prostate cancers are multifocal,, and are composed
of multiple genetically distinct cancer cell clones,,. Whether or not multiclonal primary …

Sequencing studies of breast tumour cohorts have identified many prevalent mutations, but
provide limited insight into the genomic diversity within tumours. Here we developed a …

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Cancer cells have diverse biological capabilities that are conferred by numerous genetic
aberrations and epigenetic modifications. Today's powerful technologies are enabling these …

Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of
targeted therapies and the development of high-resolution, genome-wide approaches,,,,, are …

Cancer is a multistep process that involves mutations and other alterations in oncogenes
and tumour suppressor genes. Genome sequencing studies have identified a large …