Effect of a complex environmental mixture from coal tar containing polycyclic aromatic hydrocarbons (PAH) on the tumor initiation, PAH–DNA binding and metabolic …
CP Marston, C Pereira, J Ferguson, K Fischer… - …, 2001 - academic.oup.com
Human exposure to polycyclic aromatic hydrocarbons (PAH) occurs through complex
mixtures such as coal tar. The effect of complex PAH mixtures on the activation of …
mixtures such as coal tar. The effect of complex PAH mixtures on the activation of …
Effect of a standardized complex mixture derived from coal tar on the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons in human cells in culture
B Mahadevan, CP Marston… - Chemical research in …, 2005 - ACS Publications
A complex mixture of polycyclic aromatic hydrocarbons (PAH) extracted from coal tar,
standard reference material (SRM) 1597, has been shown to initiate tumor formation in …
standard reference material (SRM) 1597, has been shown to initiate tumor formation in …
Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin
NC Hughes, W Pfau, A Hewer, J Jacob… - …, 1993 - academic.oup.com
Abstract Treatment of mouse skin with coal tar is known to initiate tumour formation, with the
carcinogenic activity associated mainly with polycyclic aromatic hydrocarbons (PAHs). A …
carcinogenic activity associated mainly with polycyclic aromatic hydrocarbons (PAHs). A …
Competitive inhibition of carcinogen‐activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar
B Mahadevan, CP Marston, A Luch… - … journal of cancer, 2007 - Wiley Online Library
A complex mixture of polycyclic aromatic hydrocarbons (PAH) extracted from coal tar, the
Standard Reference Material (SRM) 1597, was recently shown to decrease the levels of …
Standard Reference Material (SRM) 1597, was recently shown to decrease the levels of …
Altered gene expression patterns in MCF-7 cells induced by the urban dust particulate complex mixture standard reference material 1649a
B Mahadevan, C Keshava, T Musafia-Jeknic, A Pecaj… - Cancer research, 2005 - AACR
Human exposures to polycyclic aromatic hydrocarbon (PAH) occur in complex mixtures.
Here, gene expression patterns were investigated using standard reference material (SRM) …
Here, gene expression patterns were investigated using standard reference material (SRM) …
The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivo
LA Courter, A Luch, T Musafia-Jeknic, VM Arlt… - Cancer letters, 2008 - Elsevier
The carcinogenic effects of individual polycyclic aromatic hydrocarbons (PAH) are well
established. However, their potency within an environmental complex mixture is uncertain …
established. However, their potency within an environmental complex mixture is uncertain …
Tumors and DNA adducts in mice exposed to benzo [a] pyrene and coal tars: implications for risk assessment.
LS Goldstein, EH Weyand, S Safe… - Environmental …, 1998 - ehp.niehs.nih.gov
Current methods to estimate the quantitative cancer risk of complex mixtures of polycyclic
aromatic hydrocarbons (PAH) such as coal tar assume that overall potency can be derived …
aromatic hydrocarbons (PAH) such as coal tar assume that overall potency can be derived …
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites
VJ Melendez-Colon, A Luch, A Seidel… - …, 1999 - academic.oup.com
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high
carcinogenic potencies that have been linked to the etiology of human cancers through their …
carcinogenic potencies that have been linked to the etiology of human cancers through their …
Comparison of DNA adduct formation in mice fed coal tar or benzo [a] pyrene
SJ Culp, FA Beland - Carcinogenesis, 1994 - academic.oup.com
Coal tar is a complex mixture containing hundreds of compounds, including the
carcinogenic poly cyclic aromatic hydrocarbon, benzo [a] pyrene. In order to compare the …
carcinogenic poly cyclic aromatic hydrocarbon, benzo [a] pyrene. In order to compare the …
Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction …
LK Siddens, KL Bunde, TA Harper Jr… - Toxicology and applied …, 2015 - Elsevier
FVB/N mice wild-type, heterozygous or null for Cyp 1b1 were used in a two-stage skin tumor
study comparing PAH, benzo [a] pyrene (BaP), dibenzo [def, p] chrysene (DBC), and coal tar …
study comparing PAH, benzo [a] pyrene (BaP), dibenzo [def, p] chrysene (DBC), and coal tar …
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