Neuropharmacology and therapeutic potential of cannabinoids
RG Pertwee - Addiction biology, 2000 - Wiley Online Library
Mammalian tissues contain at least two types of cannabinoid receptor, CB 1, found mainly
on neurones and CB 2, found mainly in immune cells. Endogenous ligands for these …
on neurones and CB 2, found mainly in immune cells. Endogenous ligands for these …
Cannabinoid receptors and their endogenous agonists
▪ Abstract Marijuana has been in use for over 4000 years as a therapeutic and as a
recreational drug. Within the past decade, two cannabinoid receptor types have been …
recreational drug. Within the past decade, two cannabinoid receptor types have been …
The peripheral cannabinoid receptor knockout mice: an update
NE Buckley - British journal of pharmacology, 2008 - Wiley Online Library
This review gives an overview of the CB2 receptor (CB2R) knockout (CB2R−/−) mice
phenotype and the work that has been carried out using this mutant mouse. Using the …
phenotype and the work that has been carried out using this mutant mouse. Using the …
Cannabinoid receptors: nomenclature and pharmacological principles
The CB1 and CB2 cannabinoid receptors are members of the G protein-coupled receptor
(GPCR) family that are pharmacologically well defined. However, the discovery of additional …
(GPCR) family that are pharmacologically well defined. However, the discovery of additional …
Downregulation of rat brain cannabinoid binding sites after chronic Δ9-tetrahydrocannabinol treatment
FR De Fonseca, MA Gorriti, JJ Fernandez-Ruiz… - Pharmacology …, 1994 - Elsevier
Specific cannabinoid receptors have been recently described in extrapyramidal and limbic
areas and presumably might mediate the effects of marijuana exposure on behavioral …
areas and presumably might mediate the effects of marijuana exposure on behavioral …
CB1 receptor antagonist precipitates withdrawal in mice exposed to Δ9-tetrahydrocannabinol
SA Cook, JA Lowe, BR Martin - Journal of Pharmacology and Experimental …, 1998 - ASPET
Although tolerance to cannabinoids has been well established, the question of cannabinoid
dependence had been very controversial until the discovery of a cannabinoid antagonist …
dependence had been very controversial until the discovery of a cannabinoid antagonist …
Aversive effects of the synthetic cannabinoid CP 55,940 in rats
IS McGregor, CN Issakidis, G Prior - Pharmacology Biochemistry and …, 1996 - Elsevier
A series of experiments investigated the behavioral and hedonic effects of the synthetic
cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor …
cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor …
Behavioral effects of cannabinoid agents in animals
F Chaperon, MH Thiebot - Critical Reviews™ in Neurobiology, 1999 - dl.begellhouse.com
Two subtypes of cannabinoid receptors have been identified to date, the CB, receptor,
essentially located in the CNS, but also in peripheral tissues, and the CB 2 receptor, found …
essentially located in the CNS, but also in peripheral tissues, and the CB 2 receptor, found …
Cannabis: pharmacology and toxicology in animals and humans
IB Adams, BR Martin - Addiction, 1996 - Wiley Online Library
Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …