Mammalian tissues contain at least two types of cannabinoid receptor, CB 1, found mainly
on neurones and CB 2, found mainly in immune cells. Endogenous ligands for these …

▪ Abstract Marijuana has been in use for over 4000 years as a therapeutic and as a
recreational drug. Within the past decade, two cannabinoid receptor types have been …

This review gives an overview of the CB2 receptor (CB2R) knockout (CB2R−/−) mice
phenotype and the work that has been carried out using this mutant mouse. Using the …

The CB1 and CB2 cannabinoid receptors are members of the G protein-coupled receptor
(GPCR) family that are pharmacologically well defined. However, the discovery of additional …

Specific cannabinoid receptors have been recently described in extrapyramidal and limbic
areas and presumably might mediate the effects of marijuana exposure on behavioral …

Although tolerance to cannabinoids has been well established, the question of cannabinoid
dependence had been very controversial until the discovery of a cannabinoid antagonist …

A series of experiments investigated the behavioral and hedonic effects of the synthetic
cannabinoid CP 55,940 in male Wistar rats. CP 55,940 had a biphasic effect on locomotor …

Two subtypes of cannabinoid receptors have been identified to date, the CB, receptor,
essentially located in the CNS, but also in peripheral tissues, and the CB 2 receptor, found …

Cannabis is one of the most widely used drugs throughout the world. The psychoactive
constituent of cannabis, δ9‐tetrahydrocannabinol (δ9‐THC), produces a myriad of …