[HTML][HTML] FAAH−/− mice display differential tolerance, dependence, and cannabinoid receptor adaptation after Δ9-tetrahydrocannabinol and anandamide …
KW Falenski, AJ Thorpe, JE Schlosburg… - …, 2010 - nature.com
Repeated administration of Δ 9-tetrahydrocannabinol (THC), the primary psychoactive
constituent of Cannabis sativa, induces profound tolerance that correlates with …
constituent of Cannabis sativa, induces profound tolerance that correlates with …
Addictive potential of cannabinoids: the underlying neurobiology
EL Gardner - Chemistry and physics of lipids, 2002 - Elsevier
Drugs that are addictive in humans have a number of commonalities in animal model
systems—(1) they enhance electrical brain-stimulation reward in the core meso-accumbens …
systems—(1) they enhance electrical brain-stimulation reward in the core meso-accumbens …
Development of behavioral tolerance to Δ9-THC without alteration of cannabinoid receptor binding or mRNA levels in whole brain
ME Abood, C Sauss, F Fan, CL Tilton… - Pharmacology …, 1993 - Elsevier
The effect of repetitive administration of delta-9-tetrahydrocannabinol (Δ 9-THC) in mice on
behavioral and biochemical tolerance was determined in this study. Mice were injected …
behavioral and biochemical tolerance was determined in this study. Mice were injected …
Cannabinoid pharmacology.
WL Dewey - Pharmacological reviews, 1986 - ASPET
The pharmacology of the cannabinoids is characterized by at least two very provocative
phenomena. First, the multiplicity of effects. As I have mentioned throughout this review …
phenomena. First, the multiplicity of effects. As I have mentioned throughout this review …
Role of endocannabinoids and cannabinoid CB1 receptors in alcohol‐related behaviors
BL Hungund, BS Basavarajappa - … of the New York Academy of …, 2004 - Wiley Online Library
This review presents the remarkable research during the past several years indicating that
some of the pharmacological and behavioral effects of alcohol, including alcohol drinking …
some of the pharmacological and behavioral effects of alcohol, including alcohol drinking …
Novel physiologic functions of endocannabinoids as revealed through the use of mutant mice
G Kunos, S Btákai - Neurochemical research, 2001 - Springer
The presence in the mammalian brain of specific receptors for marijuana triggered a search
for endogenous ligands, several of which have been recently identified. There has been …
for endogenous ligands, several of which have been recently identified. There has been …
[PDF][PDF] Involvement of cannabinoid CB~ 1 receptors in drug addiction: effects of rimonabant on behavioral responses induced by cocaine
M Filip, A Golda, M Zaniewska, AC McCreary… - Pharmacological …, 2006 - Citeseer
A lot of evidence indicate that endocannabinoids and cannabinoid CB receptors are
implicated in drug addiction. In the present study, we investigated the effect of the …
implicated in drug addiction. In the present study, we investigated the effect of the …
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain
TH Burkey, RM Quock, P Consroe, FJ Ehlert… - European journal of …, 1997 - Elsevier
We measured (−)-5-(1, 1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-
phenol (CP 55,940)-,(−) 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl (HU-210) …
phenol (CP 55,940)-,(−) 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl (HU-210) …
Chronic CP-55,940 alters cannabinoid receptor mRNA in the rat brain: an: in situ: hybridization study
T Rubino, P Massi, G Patrini, I Venier, G Giagnoni… - …, 1994 - journals.lww.com
USING in situ hybridization we found that chronic treatment with CP-55,940 (0.4 mg kg− 1, ip
daily for 11 days), a synthetic cannabinoid receptor ligand, changed cannabinoid receptor …
daily for 11 days), a synthetic cannabinoid receptor ligand, changed cannabinoid receptor …
Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system
D Braida, M Pozzi, R Cavallini, M Sala - Neuroscience, 2001 - Elsevier
Cannabinoids appear atypical as drugs of abuse since controversial data exist concerning
the ability to lower the thresholds for electrical self-stimulation (Stark and Dews, 1980; …
the ability to lower the thresholds for electrical self-stimulation (Stark and Dews, 1980; …