Repeated administration of Δ 9-tetrahydrocannabinol (THC), the primary psychoactive
constituent of Cannabis sativa, induces profound tolerance that correlates with …

Drugs that are addictive in humans have a number of commonalities in animal model
systems—(1) they enhance electrical brain-stimulation reward in the core meso-accumbens …

The effect of repetitive administration of delta-9-tetrahydrocannabinol (Δ 9-THC) in mice on
behavioral and biochemical tolerance was determined in this study. Mice were injected …

The pharmacology of the cannabinoids is characterized by at least two very provocative
phenomena. First, the multiplicity of effects. As I have mentioned throughout this review …

This review presents the remarkable research during the past several years indicating that
some of the pharmacological and behavioral effects of alcohol, including alcohol drinking …

The presence in the mammalian brain of specific receptors for marijuana triggered a search
for endogenous ligands, several of which have been recently identified. There has been …

A lot of evidence indicate that endocannabinoids and cannabinoid CB receptors are
implicated in drug addiction. In the present study, we investigated the effect of the …

We measured (−)-5-(1, 1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl) cyclohexyl]-
phenol (CP 55,940)-,(−) 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl (HU-210) …

USING in situ hybridization we found that chronic treatment with CP-55,940 (0.4 mg kg− 1, ip
daily for 11 days), a synthetic cannabinoid receptor ligand, changed cannabinoid receptor …

Cannabinoids appear atypical as drugs of abuse since controversial data exist concerning
the ability to lower the thresholds for electrical self-stimulation (Stark and Dews, 1980; …