Originally synthesized for research purposes, indole-and pyrrole-derived synthetic
cannabinoids are the most common psychoactive compounds contained in abused products …

The Cannabis sativa plant contains more than 120 cannabinoids. With the exceptions of∆ 9-
tetrahydrocannabinol (∆ 9-THC) and cannabidiol (CBD), comparatively little is known about …

Sex-dependent differences are frequently observed in the biological and behavioural effects
of substances of abuse, including cannabis. We recently demonstrated a modulating effect …

Cannabinoids have been reported to sustain self-administration in laboratory animals;
however, genetic differences and environmental factors critical in the initiation and retention …

ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely
responsible for the psychotropic effects of cannabis—prompted research in the 1970s and …

Chronic treatment of rats with▵ 9‐tetrahydrocannabinol (▵ 9‐THC) results in tolerance to its
acute behavioral effects. In a previous study, 21‐day▵ 9‐THC treatment in rats decreased …

When Δ9-tetrahydrocannabinol (Δ9-THC, 15 mg/kg) was injected intraperitoneally twice a
day for 6 days, tolerance to its analgesic effect appeared to be complete. Chronic exposure …

The recent discovery of arachidonylethanolamide (anandamide), an endogenous ligand for
cannabinoid receptors, and the synthesis of SR141716A, a cannabinoid antagonist …

The receptor occupancy required to produce cannabinoid effects in the central nervous
system was determined in both a neurochemical and a behavioral assay for cannabinoid …

Rationale: Repeated exposure to several drugs of abuse has been reported to induce
behavioural sensitization. So far no evidence has been provided that such a phenomenon …