BACKGROUND The complexity of fertilization failure during assisted reproductive
technologies (ART) is often under-appreciated, as this failure can occur at any number of …

The capacity of intracytoplasmic sperm injection (ICSI) to permit almost any type of
spermatozoa to fertilize oocytes has made it the most successful treatment for male factor …

Embryonic development is readily compromised by imperfections introduced during the
process of oocyte maturation. We discuss the nature and causes of these imperfections …

BACKGROUND Total fertilization failure (TFF) is the failure of all metaphase II oocytes to
fertilize in ART cycles. The phenomenon represents a known cause of infertility, affecting 1 …

Assisted reproduction technology (ART) has become an attractive option for infertility
treatment and holds tremendous promise. However, at present, there is still room for …

Background The first clues to the process of gamete activation date back to nearly 60 years
ago. The mutual activation of gametes is a crucial event during fertilization. In the testis and …

BACKGROUND In a growth phase occurring during most of folliculogenesis, the oocyte
produces and accumulates molecules and organelles that are fundamental for the …

Objective To test whether abnormally fertilized oocyte (AFO)–derived blastocysts are diploid
and can be rescued for clinical use. Design Longitudinal-cohort study from January 2015 to …

Abstract STUDY QUESTION Do the ICSI-related procedural timings and operators affect the
outcomes of an ART cycle? SUMMARY ANSWER The ICSI-related timings and operators do …

Purpose To assess the efficiency of IVM in patients with repeated ART failure due to
resistant ovary syndrome or due to deficient oocyte maturation. Methods Clinical and …