[HTML][HTML] The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases
The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …
can be initiated in response to various exogenous or endogenous danger signals …
[HTML][HTML] The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
Development of small molecule inhibitors targeting NLRP3 inflammasome pathway for inflammatory diseases
X Zhang, A Xu, J Lv, Q Zhang, Y Ran, C Wei… - European journal of …, 2020 - Elsevier
NLRP3 (Nod-like receptor protein 3) belongs to the NOD-like receptor family, which is
activated by pathogen and damage-associated signals to form a multimeric protein complex …
activated by pathogen and damage-associated signals to form a multimeric protein complex …
[HTML][HTML] Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases
Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
[HTML][HTML] The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors
X Zhan, Q Li, G Xu, X Xiao, Z Bai - Frontiers in Immunology, 2023 - frontiersin.org
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …
Pharmacological inhibition of the NLRP3 inflammasome: structure, molecular activation, and inhibitor-NLRP3 interaction
Q Ma - Pharmacological reviews, 2023 - ASPET
The nucleotide-binding, oligomerization domain-like receptor family pyrin domain containing
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
3 (NLRP3) inflammasome is a multiprotein complex that combines sensing, regulation, and …
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
L Vande Walle, M Lamkanfi - Nature Reviews Drug Discovery, 2024 - nature.com
Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …
world. As central instigators of the inflammatory response to infection and tissue damage …
The signaling pathways regulating NLRP3 inflammasome activation
M Chen, X Ye, X He, D Ouyang - Inflammation, 2021 - Springer
The NLRP3 inflammasome is a multi-molecular complex that acts as a molecular platform to
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …
mediate caspase-1 activation, leading to IL-1β/IL-18 maturation and release in cells …
NLRP3 inflammasome and inflammatory diseases
Z Wang, S Zhang, Y Xiao, W Zhang… - Oxidative medicine …, 2020 - Wiley Online Library
Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …
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