Background & Aims Leptin, the protein product of the ob gene, increases energy
expenditure and reduces food intake, thereby promoting weight reduction. Leptin also …

Objective: Weight regain contributes to the therapeutic failure in 15–20% of type 2 diabetic
patients after Roux-en-Y gastric bypass surgery (RYGB), and the mechanism remains …

Bariatric surgery improves glucose homeostasis and alters gut hormones partly independent
of weight loss. Leptin plays a role in these processes; levels are decreased following …

OBJECTIVE: In the severely obese, Roux-en-Y gastric bypass (RYGB) reverses diabetes
before body weight loss occurs. We determined changes in protein expression of insulin …

The molecular mechanisms implicated in pronounced weight loss and metabolic benefits
after bariatric surgery are still unknown. Adipocyte phenotype and metabolism have not …

Although the prevalence of obesity has increased dramatically throughout the world during
the last 25 yr, its long-term control remains poor. Currently, only gastrointestinal weight loss …

Purpose We investigated whether metabolic phenotype improvements following gastric
bypass are associated with gastric resection strategy in high-fat diet-induced obese (DIO) …

Purpose The purpose of this study is to evaluate the relationship between body composition,
basal metabolic rate (BMR), and serum concentrations of leptin with long-term weight regain …

Background The mechanisms by which Roux-en-Y gastric bypass surgery (RYGB) so
effectively lowers body weight and improves glycemic control are not well understood, and …

Gastrointestinal weight‐loss surgery (GIWLS) is currently the most effective treatment for
severe obesity, with Roux en‐Y gastric bypass (RYGB) among the best of the available …