Radiation therapy is a major treatment in hepatocellular carcinoma (HCC). Yet, this
treatment is ineffective in HCC due to lack of radiosensitivity. For this reason, we examined …

Objective To study the radiosensitizing potential of Berberine and the underlying mechanism
in human hepatocarcinoma (HepG2) cells. Methods HepG2 cells were challenged with X …

Radiation therapy is an important treatment approach for esophageal squamous cell
carcinoma (ESCC). However, how to promote radiation sensitivity in ESCC remains a …

Berberine, an isoquinoline plant alkaloid, has been known to generate a wide variety of
biochemical and pharmacological effects. In order to elucidate the molecular mechanism for …

Aims: High constitutive expression of Nrf2 has been found in many types of cancers, and this
high level of Nrf2 also favors resistance to drugs and radiation. Here we investigate how …

Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their
clinical outcomes are highly limited by the resistance of malignant tumors to these therapies …

NF-E2-related factor 2 (Nrf2) has been identified as a master regulatory factor in the
protection of cells from oxidative and electrophilic stress. However, overexpression of Nrf2 in …

Background Hepatocellular carcinoma (HCC) is the seventh most common malignancy and
the third leading cause of cancer-related death worldwide with an extremely grim prognosis …

Liver cancer, otherwise known as hepatocellular carcinoma, is a chronic disease condition
with an excessive deposition and growth of malignant cells in the body. The high incidence …

Berberine (BBR) is the main component of Coptidis rhizoma, the dried rhizome of Coptis
chinensis and is a potential plant alkaloid used for the treatment of cancer due to its high …