[HTML][HTML] Induction of apoptosis by berberine in hepatocellular carcinoma HepG2 cells via downregulation of NF-κB

M Li, M Zhang, Z Zhang, N Liu, X Han, Q Liu… - Oncology …, 2017 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is highly resistant to traditional chemotherapeutic
approaches, which causes difficulty in the development of effective drugs for the treatment of …

[HTML][HTML] Nrf2 down-regulation by camptothecin favors inhibiting invasion, metastasis and angiogenesis in hepatocellular carcinoma

Q Liu, S Zhao, F Meng, H Wang, L Sun, G Li… - Frontiers in …, 2021 - frontiersin.org
Higher oxidant stress capacity could promote invasion and metastasis. A previous study
showed hepatocellular carcinoma (HCC) expressed more Nrf2 than para-carcinoma tissue …

Protective effects of berberine on radiation-induced lung injury via intercellular adhesion molecular-1 and transforming growth factor-beta-1 in patients with lung …

Y Liu, H Yu, C Zhang, Y Cheng, L Hu, X Meng… - European Journal of …, 2008 - Elsevier
PURPOSE: To investigate the protective effects of berberine on radiation-induced lung injury
(RILI) in non-small cell lung cancer (NSCLC) patients treated with radiotherapy. PATIENTS …

Berberine induces cell cycle arrest in cholangiocarcinoma cell lines via inhibition of NF-κB and STAT3 pathways

N Puthdee, W Seubwai… - Biological and …, 2017 - jstage.jst.go.jp
Berberine is a natural compound found in several herbs. Anticancer activity of berberine was
reported in several cancers, however, little is known regarding the effects of berberine …

[HTML][HTML] Antiproliferation of berberine is mediated by epigenetic modification of constitutive androstane receptor (CAR) metabolic pathway in hepatoma cells

L Zhang, XJ Miao, X Wang, HH Pan, P Li, H Ren… - Scientific Reports, 2016 - nature.com
Constitutive androstane receptor (CAR) regulates hepatic xenobiotic and energy
metabolism, as well as promotes cell growth and hepatocarcinogenesis. Berberine is an …

[HTML][HTML] Berberine targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and cytochrome-c/caspase signaling to suppress human cancer cell growth

L Fu, W Chen, W Guo, J Wang, Y Tian, D Shi, X Zhang… - PloS one, 2013 - journals.plos.org
Berberine (BBR), an isoquinoline derivative alkaloid isolated from Chinese herbs, has a
long history of uses for the treatment of multiple diseases, including cancers. However, the …

In vitro and in vivo superior radiosensitizing effect of berbamine for head and neck squamous cell carcinoma

H Zhu, S Ruan, F Jia, J Chu, Y Zhu… - OncoTargets and …, 2018 - Taylor & Francis
Background Berbamine (BBM), one of the bis-benzylisoquinoline products isolated from
Berberis amurensis, has been demonstrated for its anticancer effect against leukemia …

Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1α expression

C Zhang, X Yang, Q Zhang, B Yang, L Xu… - Acta oto …, 2014 - Taylor & Francis
Conclusion: Berberine confers radiosensitivity on nasopharyngeal carcinoma (NPC) and
this is associated with the down-regulation of hypoxia-inducible factor-1α (HIF-1α) and …

Radiosensitizing effect of bromelain using tumor mice model via Ki-67 and PARP-1 inhibition

MH Mekkawy, HA Fahmy, AS Nada… - Integrative Cancer …, 2021 - journals.sagepub.com
Recent reports have shown that bromelain (BL), a pineapple extract, acts as an adjuvant
therapy in cancer treatment and prevention of carcinogenesis. The present study was …

[HTML][HTML] Berberine inhibits carcinogenesis through antagonizing the ATX-LPA-LPAR2-p38-leptin axis in a mouse hepatoma model

G Ren, JH Guo, CL Feng, YW Ding, B Dong… - Molecular Therapy …, 2022 - cell.com
Chemoprevention of hepatocellular carcinoma (HCC) is highly desirable in clinic. Berberine
(BBR) is reported to play potential roles in cancer treatment and prevention. We studied the …