The method of supersaturation for achieving high drug loads in lipid-based formulations is
under exploited and relatively unexplored, especially in the case of solid-state lipid-based …

Supersaturated silica-lipid hybrid (super-SLH) drug carriers are a recent strategy to improve
the drug loading of oral solid lipid based formulations, however they are yet to be studied in …

Two widely applied enabling drug delivery approaches, self-nanoemulsifying drug delivery
systems (SNEDDS) and amorphous solid dispersions (ASD), were combined, with the aim of …

Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system
under investigation for their aptitude to enhance the oral bioavailability of poorly water …

Lyophilization was investigated to produce a powdery silica–lipid hybrid (SLH) carrier for
oral delivery of poorly water‐soluble drugs. The silica to lipid ratio, incorporation of …

A silica-lipid hybrid (SLH) microcapsule system for oral delivery of poorly water-soluble
drugs is reported for the first time. For the model drug celecoxib (CEL), SLH microcapsules …

Amorphous solid dispersion stands out among different formulation strategies for the
improvement of dissolution rate and bioavailability via generating supersaturated drug …

Clinical trials addressing the viability of lipid and nanoparticle-based solid dosage forms for
the oral delivery of poorly water-soluble drugs are limited to date. This Phase I study aimed …

Lipid-based formulations, in particular supersaturated lipid-based formulations, are
important delivery approaches when formulating challenging compounds, as especially low …

Oral absorption of weakly basic drugs (eg cinnarizine (CIN)) is limited by their pH dependent
precipitation in intestinal conditions. To overcome this challenge, a novel drug delivery …